Electrochemical Synthesis of N-Substituted 5-(1H-Indol-3-yl)-1,3,4-oxadiazole-2-amines: A Mild and Green Approach

The work employs aliphatic and aromatic isothiocyanates and utilizes electrochemical techniques for the reaction. The process involves a two-electrode system with a conductive carbon working electrode and a counter electrode. An appropriate electrolyte, such as an organic solvent, is used, and upon applying an electric potential, electrochemical oxidation and nucleophilic substitution reactions occur, leading to the formation of the desired 1,3,4-oxadiazole-2-amines. Key advantages of this electrochemical method include its high functional group tolerance, enabling the synthesis of a wide range of compounds with different substituents. The reaction conditions can be fine-tuned for high conversion and selectivity, ensuring good overall yields of the target products. Additionally, the electrochemical method offers sustainability and convenience, making it a promising alternative to traditional synthesis. The use of electricity as an energy source is more environmentally friendly compared to traditional heating methods, contributing to greener and eco-friendly chemical processes.