The Effects of Crocus sativus (Saffron) on ADHD: A Systematic Review

被引：1
作者：
Seyedi-Sahebari, Sepideh [1 ]
Farhang, Sara [2 ]
Araj-Khodaei, Mostafa [3 ]
Akhondzadeh, Shahin [4 ]
Naseri, Amirreza [1 ,5 ]
Sanaie, Sarvin [6 ]
Frounchi, Negin [5 ]
机构：
[1] Tabriz Univ Med Sci, Student Res Comm, Golgasht St, Tabriz 516615731, East Azerbaijan, Iran
[2] Tabriz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Tabriz, Iran
[3] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran
[4] Univ Tehran Med Sci, Roozbeh Hosp, Psychiat Res Ctr, Tehran, Iran
[5] Tabriz Univ Med Sci, Iranian EBM Centre, Res Ctr Evidence Based Med, Joanna Briggs Inst JBI,Ctr Excellence, Tabriz, Iran
[6] Tabriz Univ Med Sci, Aging Res Inst, Res Ctr Integrat Med Aging, Golgasht St, Tabriz 516615731, East Azerbaijan, Iran
来源：
JOURNAL OF ATTENTION DISORDERS | 2024年 / 28卷 / 01期
关键词：
Crocus sativus; saffron; attention deficit disorder with hyperactivity; ADHD; systematic review; DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DOUBLE-BLIND; CHILDREN; METHYLPHENIDATE; PATHOPHYSIOLOGY; CONSTITUENTS; ADOLESCENTS; MECHANISMS; L;
D O I：
10.1177/10870547231203176
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Background and Aim: Crocus sativus also known as saffron, is one of the most popular traditional plants. This study aims to evaluate the efficacy and safety of saffron extracts in ADHD.Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review articles, commentaries, letters, observational studies, thesis, animal studies, in-vitro studies, and conference abstracts were not included. The risk of bias in randomized studies was evaluated based on the Cochrane RoB.2, and risk of bias in pre-post intervention studies was assessed using the ROBINS-I tool.Results: Four studies met our inclusion criteria with a total of 118 patients. The results manifested an efficient role of saffron as either an adjuvant therapy to MPH or a single therapy against ADHD, without significant safety issues.Discussion: Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested.
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收藏
页码：14 / 24
页数：11
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