Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health

被引：86

作者：

Li, Ting ^{[1
,2
,3
]}

Wang, Zhenlong ^{[1
,2
]}

Guo, Jianhua ^{[4
]}

de la Fuente-Nunez, Cesar ^{[5
,6
,7
,8
,9
]}

Wang, Jinquan ^{[1
,2
]}

Han, Bing ^{[1
,2
]}

Tao, Hui ^{[1
,2
]}

Liu, Jie ^{[1
,2
]}

Wang, Xiumin ^{[1
,2
]}

机构：

[1] Chinese Acad Agr Sci, Inst Feed Res, Beijing 100081, Peoples R China

[2] Minist Agr & Rural Affairs, Key Lab Feed Biotechnol, Beijing 100081, Peoples R China

[3] Beijing Inst Biotechnol, State Key Lab Pathogen & Biosecur, 20 Dongda St, Beijing 100071, Peoples R China

[4] Univ Queensland, Australian Ctr Water & Environm Biotechnol ACWEB, St Lucia, Qld 4072, Australia

[5] Univ Penn, Inst Biomed Informat, Inst Translat Med & Therapeut, Perelman Sch Med,Machine Biol Grp,Dept Psychiat, Philadelphia, PA USA

[6] Univ Penn, Inst Biomed Informat, Inst Translat Med & Therapeut, Perelman Sch Med,Machine Biol Grp,Dept Microbiol, Philadelphia, PA USA

[7] Univ Penn, Sch Engn & Appl Sci, Dept Bioengn, Philadelphia, PA USA

[8] Univ Penn, Sch Engn & Appl Sci, Dept Chem & Biomol Engn, Philadelphia, PA USA

[9] Univ Penn, Penn Inst Computat Sci, Philadelphia, PA USA

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2023年 / 860卷

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Bacterial resistance; Antibiotics; Mechanism of action; Antimicrobial peptides; Strategies; Global health; MULTIDRUG EFFLUX PUMP; ANTIMICROBIAL PEPTIDE RESISTANCE; ENTERICA SEROVAR TYPHIMURIUM; GRAM-NEGATIVE BACTERIA; STAPHYLOCOCCUS-AUREUS RESISTANCE; KLEBSIELLA-PNEUMONIAE VIRULENCE; PSEUDOMONAS-AERUGINOSA BIOFILMS; PLASMID-MEDIATED RESISTANCE; MOLECULAR-GENETIC-ANALYSIS; SMALL-COLONY VARIANTS;

D O I：

10.1016/j.scitotenv.2022.160461

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The spread of bacterial drug resistance has posed a severe threat to public health globally. Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbalmedicines, conventional antibiotics, and antimicrobial peptides. We summarize the influence of bacterial drug resistance on global health and its economic burden while highlighting the resistance mechanisms developed by bacteria. Based on the One Health concept, we propose 4A strategies to combat bacterial resistance, including prudent Application of antibacterial agents, Administration, Assays, and Alternatives to antibiotics. Finally, we identify several opportunities and unsolved questions warranting future exploration for combating bacterial resistance, such as predicting genetic bacterial resistance through the use of more effective techniques, surveying both genetic determinants of bacterial resistance and the transmission dynamics of antibiotic resistance genes (ARGs).

引用

页数：20

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