Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation

被引：5

作者：

Najjar, Sarah A. ^{[1
]}

Hung, Lin Y. ^{[1
]}

Margolis, Kara Gross ^{[1
,2
]}

机构：

[1] NYU Coll Dent, Dept Mol Pathobiol, New York, NY 10010 USA

[2] NYU Langone Med Ctr, Dept Pediat, New York, NY 10016 USA

来源：

COMPREHENSIVE PHYSIOLOGY | 2023年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

IRRITABLE-BOWEL-SYNDROME; ENTERIC NERVOUS-SYSTEM; GUINEA-PIG ILEUM; DELAYED-TYPE HYPERSENSITIVITY; FAST SYNAPTIC-TRANSMISSION; 5-HT3 RECEPTOR ANTAGONIST; MIGRATING MOTOR COMPLEXES; PLACEBO-CONTROLLED TRIAL; CHAIN FATTY-ACIDS; INTERSTITIAL-CELLS;

D O I：

10.1002/cphy.c220024

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Although it is most well-known for its roles in central nervous system (CNS) function, the vast majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) tract. 5-HT is synthesized mostly by enterochromaffin (EC) cells of the GI epithelium and, in small part, by neurons of the enteric nervous system (ENS). The GI tract contains an array of broadly distributed 5-HT receptors, which participate in functions such as motility, sensation, inflammation, and neurogenesis. The roles of 5-HT in these functions are reviewed, as well as its role in the pathophysiology of disorders of gut-brain interaction (DGBIs) and inflammatory bowel diseases (IBD). & COPY; 2023 American Physiological Society. Compr Physiol 13:4851-4868, 2023.

引用

页码：4851 / 4868

页数：18

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