Advancements in dextran-based nanocarriers for treatment and imaging of breast cancer

被引:89
作者
Khan, Mohammad Sameer [1 ]
Gowda, B. H. Jaswanth [2 ]
Nasir, Nazim [3 ]
Wahab, Shadma [4 ]
Pichika, Mallikarjuna Rao [5 ]
Sahebkar, Amirhossein [6 ,7 ]
Kesharwani, Prashant [1 ,8 ]
机构
[1] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India
[2] Yenepoya, Yenepoya Pharm Coll & Res Ctr, Dept Pharmaceut, Mangalore 575018, Karnataka, India
[3] Coll Appl Med Sci, Dept Basic Med Sci, Khamis Mushait, Saudi Arabia
[4] King Khalid Univ, Coll Pharm, Dept Pharmacognosy, Abha 61421, Saudi Arabia
[5] Int Med Univ, Sch Pharm, Pharmaceut Chem, Kuala Lumpur, Malaysia
[6] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[7] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
[8] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Dept Pharmacol, Chennai, India
关键词
Dextran; Breast cancer; Targeted drug delivery; Chemotherapy; Immunotherapy; GROWTH IN-VITRO; TARGETED DELIVERY; DRUG-DELIVERY; POLYMERIC MICELLES; DEAE-DEXTRAN; NANOPARTICLES; THERAPY; CISPLATIN; HYPERTHERMIA; CHEMOTHERAPY;
D O I
10.1016/j.ijpharm.2023.123276
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Breast cancer is the most prevalent type of cancer worldwide, particularly among women, with substantial side effects after therapy. Despite the availability of numerous therapeutic approaches, particularly chemotherapy, the survival rates for breast cancer have declined over time. The therapies currently utilized for breast cancer treatment do not specifically target cancerous cells, resulting in significant adverse effects and potential harm to healthy cells alongside the cancer cells. As a result, nanoparticle-based drug delivery systems have emerged. Among various types of nanoparticles, natural polysaccharide-based nanoparticles have gained significant attention due to their ability to precisely control the drug release and achieve targeted drug delivery. Moreover, polysaccharides are biocompatible, biodegradable, easily modifiable, and renewable, which makes them a unique material for nanoformulation. In recent years, dextran and its derivatives have gained much interest in the field of breast cancer therapy. Dextran is a hydrophilic polysaccharide composed of a main chain formed by & alpha;-1,6 linked glucopyranoside residues and a side chain composed of residues linked in & alpha;-1,2/3/4 positions. Different dextran-antitumor medication conjugates enhance the efficacy of anticancer agents. With this context, the present review provides brief insights into dextran and its modification. Further, it meticulously discusses the role of dextran-based nanoparticles in breast cancer therapy and imaging, followed by snippets on their toxicity. Lastly, it presents clinical trials and future perspectives of dextran-based nanoparticles in breast cancer treatment.
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页数:18
相关论文
共 132 条
[61]   Chemosensitizing indomethacin-conjugated dextran-based micelles for effective delivery of paclitaxel in resistant breast cancer therapy [J].
Ji, Weiping ;
Wang, Bo ;
Fan, Qiuping ;
Xu, Chao ;
He, Youwu ;
Chen, Youfen .
PLOS ONE, 2017, 12 (07)
[62]  
Johnson-Arbor K., 2021, XPHARM COMPR PHARM R, P1
[63]   Gold nanoparticles and gold nanorods in the landscape of cancer therapy [J].
Kesharwani, Prashant ;
Ma, Ruiyang ;
Sang, Liang ;
Fatima, Mahak ;
Sheikh, Afsana ;
Abourehab, Mohammed A. S. ;
Gupta, Neelima ;
Chen, Zhe-Sheng ;
Zhou, Yun .
MOLECULAR CANCER, 2023, 22 (01)
[64]   A combinatorial delivery of survivin targeted siRNA using cancer selective nanoparticles for triple negative breast cancer therapy [J].
Kesharwani, Prashant ;
Sheikh, Afsana ;
Abourehab, Mohammed A. S. ;
Salve, Rajesh ;
Gajbhiye, Virendra .
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2023, 80
[65]   Dendrimer as nanocarrier for drug delivery [J].
Kesharwani, Prashant ;
Jain, Keerti ;
Jain, Narendra Kumar .
PROGRESS IN POLYMER SCIENCE, 2014, 39 (02) :268-307
[66]   Biophysical properties of carboxymethyl derivatives of mannan and dextran [J].
Korcova, Jana ;
Machova, Eva ;
Filip, Jaroslav ;
Bystricky, Slavomir .
CARBOHYDRATE POLYMERS, 2015, 134 :6-11
[67]  
Kruh Gary D., 1993, Current Opinion in Oncology, V5, P1029, DOI 10.1097/00001622-199311000-00014
[68]  
Lakshmi M., 2020, ALTERN MED UPDAT, DOI DOI 10.5772/INTECHOPEN.94040
[69]   Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis [J].
Li, Mingqiang ;
Tang, Zhaohui ;
Zhang, Yu ;
Lv, Shixian ;
Li, Quanshun ;
Chen, Xuesi .
ACTA BIOMATERIALIA, 2015, 18 :132-143
[70]   LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer [J].
Li, Mingqiang ;
Tang, Zhaohui ;
Zhang, Yu ;
Lv, Shixian ;
Yu, Haiyang ;
Zhang, Dawei ;
Hong, Hua ;
Chen, Xuesi .
JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (22) :3490-3499