Toxicity and mutagenicity studies of 6PPD-quinone in a marine invertebrate species and bacteria

被引:8
作者
Botelho, Marina Tenorio [1 ]
Militao, Gabriely Groto [1 ]
Brinkmann, Markus [2 ,3 ,4 ]
Umbuzeiro, Gisela de Aragao [1 ,5 ]
机构
[1] Univ Estadual Campinas, Fac Tecnol, UNICAMP, Limeira, SP, Brazil
[2] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK, Canada
[3] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK, Canada
[4] Univ Saskatchewan, Global Inst Water Secur, Saskatoon, SK, Canada
[5] Univ Estadual Campinas, Sch Technol, Limeira Campus1,Rua Paschoal Marmo,1888, BR-13484332 Limeira, SP, Brazil
关键词
acute toxicity; crustacean; hemocytes; Salmonella; microsome assay; SALMONELLA; QUINONES;
D O I
10.1002/em.22560
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
N-(1,3-dimethylbutyl)-N & PRIME;-phenyl-p-phenylenediamine-quinone (6PPD-quinone), an oxidation product of the tire additive, 6PPD, has been associated with high mortality of salmonids (0.1 & mu;g/L). The objective of this study was to determine the acute toxicity using neonates and mutagenicity (micronuclei in hemolymph of exposed adults) of 6PPD-quinone in the marine amphipod Parhyale hawaiensis. Also, we studied its mutagenicity in the Salmonella/microsome assay using five strains of Salmonella with and without metabolic system (rat liver S9, 5%). 6PPD-quinone did not present acute toxicity to P. hawaiensis from 31.25 to 500 & mu;g/L. Micronuclei frequency increased after 96 h-exposure to 6PPD-quinone (250 and 500 & mu;g/L) when compared to the negative control. 6PPD-quinone also showed a weak mutagenic effect for TA100 only in the presence of S9. We conclude that 6PPD-quinone is mutagenic to P. hawaiensis and weakly mutagenic to bacteria. Our work provides information for future risk assessment of the presence of 6PPD-quinone in the aquatic environment.
引用
收藏
页码:335 / 341
页数:7
相关论文
共 37 条
  • [1] Development of an acute toxicity test with the tropical marine amphipod Parhyale hawaiensis
    Artal, Mariana Coletty
    dos Santos, Amanda
    Henry, Theodore Burdick
    Umbuzeiro, Gisela de Aragao
    [J]. ECOTOXICOLOGY, 2018, 27 (02) : 103 - 108
  • [2] Role of quinones in toxicology
    Bolton, JL
    Trush, MA
    Penning, TM
    Dryhurst, G
    Monks, TJ
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2000, 13 (03) : 135 - 160
  • [3] Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects
    Bolton, Judy L.
    Dunlap, Tareisha
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2017, 30 (01) : 13 - 37
  • [4] Genotoxic effects of silver nanoparticles on a tropical marine amphipod via feeding exposure
    Botelho, Marina Tenorio
    Passos, Maria Jose de Arruda Rocha Campos
    Trevizani, Tailisi Hoppe
    Figueira, Rubens Cesar Lopes
    Umbuzeiro, Gisela de Aragao
    Gomes, Vicente
    [J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022, 881
  • [5] Acute Toxicity of the Tire Rubber-Derived Chemical 6PPD-quinone to Four Fishes of Commercial, Cultural, and Ecological Importance
    Brinkmann, Markus
    Montgomery, David
    Selinger, Summer
    Miller, Justin G. P.
    Stock, Eric
    Alcaraz, Alper James
    Challis, Jonathan K.
    Weber, Lynn
    Janz, David
    Hecker, Markus
    Wiseman, Steve
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2022, 9 (04) : 333 - 338
  • [6] New Evidence of Rubber-Derived Quinones in Water, Air, and Soil
    Cao, Guodong
    Wang, Wei
    Zhang, Jing
    Wu, Pengfei
    Zhao, Xingchen
    Yang, Zhu
    Hu, Di
    Cai, Zongwei
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 56 (07) : 4142 - 4150
  • [7] Occurrences of Tire Rubber-Derived Contaminants in Cold-Climate Urban Runoff
    Challis, J. K.
    Popick, H.
    Prajapati, S.
    Harder, P.
    Giesy, J. P.
    McPhedran, K.
    Brinkmann, M.
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2021, 8 (11): : 961 - 967
  • [8] Mutagenicity and toxicity studies of p-phenylenediamine and its derivatives
    Chung, KT
    Murdock, CA
    Stevens, SE
    Li, YS
    Wei, CI
    Huang, TS
    Chou, MW
    [J]. TOXICOLOGY LETTERS, 1995, 81 (01) : 23 - 32
  • [9] Chiral perspective evaluations: Enantioselective hydrolysis of 6PPD and 6PPD-quinone in water and enantioselective toxicity to Gobiocypris rarus and Oncorhynchus mykiss
    Di, Shanshan
    Liu, Zhenzhen
    Zhao, Huiyu
    Li, Ying
    Qi, Peipei
    Wang, Zhiwei
    Xu, Hao
    Jin, Yuanxiang
    Wang, Xinquan
    [J]. ENVIRONMENT INTERNATIONAL, 2022, 166
  • [10] Acute Toxicity Testing of the Tire Rubber-Derived Chemical 6PPD-quinone on Atlantic Salmon (Salmo salar) and Brown Trout (Salmo trutta)
    Foldvik, Anders
    Kryuchkov, Fedor
    Sandodden, Roar
    Uhlig, Silvio
    [J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2022, 41 (12) : 3041 - 3045