The Mechanisms of Ferroptosis Under Hypoxia

被引：70

作者：

Gao, Xin ^{[1
,2
]}

Hu, Wei ^{[3
]}

Qian, Dianlun ^{[4
]}

Bai, Xiangfeng ^{[4
]}

He, Huilin ^{[1
]}

Li, Lin ^{[1
]}

Sun, Shibo ^{[1
]}

机构：

[1] Kunming Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, 295 Xichang Rd, Kunming 650032, Peoples R China

[2] Kunming Med Univ, 2020 Clin Med Class 6, Kunming 650500, Peoples R China

[3] Kunming Med Univ, Affiliated Hosp 1, Dept Cardiol, Kunming 650032, Peoples R China

[4] Kunming Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Kunming 650032, Peoples R China

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2023年 / 43卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Ferroptosis; Hypoxia; Hypoxia-inducible factor; Lipid peroxidation; System Xc; MITOCHONDRIAL DYSFUNCTION; ISCHEMIA-REPERFUSION; CEREBRAL-ISCHEMIA; SIGNALING PATHWAY; OXIDATIVE STRESS; CELL-DEATH; SYSTEM; IRON; ACTIVATION; PROTECTS;

D O I：

10.1007/s10571-023-01388-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ferroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative stress and cell death. Iron, lipid, and multiple signaling pathways precisely control the occurrence and implementation of ferroptosis. The pathways mainly include Nrf2/HO-1 signaling pathway, p62/Keap1/Nrf2 signaling pathway. Activating p62/Keap1/Nrf2 signaling pathway inhibits ferroptosis. Nrf2/HO-1 signaling pathway promotes ferroptosis. Furthermore, some factors also participate in the occurrence of ferroptosis under hypoxia, such as HIF-1, NCOA4, DMT1. Meanwhile, ferroptosis is related with hypoxia-related diseases, such as MIRI, cancers, and AKI. Accordingly, ferroptosis appears to be a therapeutic target for hypoxia-related diseases.

引用

页码：3329 / 3341

页数：13

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