Novelties in the pharmacological approaches for chronic heart failure: new drugs and cardiovascular targets

被引：7

作者：

Correale, Michele ^{[1
]}

Tricarico, Lucia ^{[1
]}

Croella, Francesca ^{[2
]}

Alfieri, Simona ^{[2
]}

Fioretti, Francesco ^{[3
]}

Brunetti, Natale Daniele ^{[2
]}

Inciardi, Riccardo M. ^{[3
]}

Nodari, Savina ^{[3
]}

机构：

[1] Policlin Riuniti Univ Hosp, Dept Cardiothorac, Foggia, Italy

[2] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy

[3] Univ Brescia, ASST Spedali Civili Hosp, Dept Med & Surg Specialties, Cardiol Sect, Brescia, Italy

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2023年 / 10卷

关键词：

new drugs; therapy targets; heart failure; cardiac metabolism; mitochondrial function; CGMP pathway; SOLUBLE GUANYLATE-CYCLASE; REDUCED EJECTION FRACTION; FATTY-ACID OXIDATION; LEFT-VENTRICULAR HYPERTROPHY; RANDOMIZED CONTROLLED-TRIAL; COTRANSPORTER; INHIBITION; DOUBLE-BLIND; METABOLIC MODULATOR; CLINICAL-TRIAL; NATRIURETIC PEPTIDE;

D O I：

10.3389/fcvm.2023.1157472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite recent advances in chronic heart failure (HF) management, the prognosis of HF patients is poor. This highlights the need for researching new drugs targeting, beyond neurohumoral and hemodynamic modulation approach, such as cardiomyocyte metabolism, myocardial interstitium, intracellular regulation and NO-sGC pathway. In this review we report main novelties on new possible pharmacological targets for HF therapy, mainly on new drugs acting on cardiac metabolism, GCs-cGMP pathway, mitochondrial function and intracellular calcium dysregulation.

引用

页数：19

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