A chronic wound model to investigate skin cellular senescence

被引：0

作者：

Wyles, Saranya P. ^{[1
]}

Dashti, Parisa ^{[1
]}

Pirtskhalava, Tamar ^{[2
]}

Tekin, Burak ^{[3
]}

Inman, Christina ^{[2
]}

Gomez, Lilian Sales ^{[4
]}

Lagnado, Anthony B. ^{[4
]}

Prata, Larissa ^{[2
]}

Jurk, Diana ^{[2
]}

Passos, Joao F. ^{[1
,2
]}

Tchkonia, Tamar ^{[2
]}

Kirkland, James L. ^{[2
]}

机构：

[1] Mayo Clin, Dept Dermatol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Med, Div Gen Internal Med, Rochester, MN 55905 USA

来源：

AGING-US | 2023年 / 15卷 / 08期

基金：

美国国家卫生研究院;

关键词：

wound healing; cellular senescence; chronic wound; re-epithelization; skin; SECRETORY PHENOTYPE; GROWTH-FACTOR; STEM-CELLS; INHIBITION; HAIR; FIBROBLASTS; CHALLENGES; MECHANISM; CATALASE;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound healing phase. In contrast, persistent senescence, as observed in chronic wounds, contributes to delayed closure. Herein we describe a chronic wound murine model and its cellular senescence profile, including the senescence-associated secretory phenotype.

引用

页码：2852 / 2862

页数：11

共 54 条

[1] The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation [J].