Transition metal-free electrochemical fluorotrifluoromethylation of Styrenes

被引：9

作者：

Lu, Yi ^{[1
]}

Liu, Zhirui ^{[1
]}

Liu, Chao ^{[1
]}

Wu, Yunpeng ^{[1
]}

Li, Lu ^{[1
]}

Liu, Siyuan ^{[1
]}

Wang, Hong ^{[1
]}

Gao, Wei ^{[1
]}

Liu, Zhenxian ^{[2
]}

Chen, Jianbin ^{[1
,2
]}

机构：

[1] Qilu Univ Technol, Shandong Acad Sci, Sch Chem & Chem Engn, Shandong Prov Key Lab Mol Engn,State Key Lab Bioba, Jinan 250353, Peoples R China

[2] Qilu Univ Technol, Shandong Acad Sci, Intellectual Property Operat Management Off, Jinan 250353, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 05期

基金：

中国国家自然科学基金;

关键词：

FLUORINATION; ALKENES; TRIFLUOROMETHYLATION;

D O I：

10.1039/d2qo01947g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally friendly electrochemical fluorotrifluoromethylation of styrenes was developed via the tandem processes of electro-oxidation and radical and nucleophilic addition. By using commercial CF3SO2Na and Et3N center dot 3HF as the CF3 and F sources, respectively, a series of potentially bio-active multi-site F-containing compounds were obtained in moderate to good yields. This fluorotrifluoromethylation strategy is catalyst- and oxidant-free, and demonstrates mild conditions and high step economy features. In addition, several analytical methods, including cyclic voltammetry and control experiments, were conducted to investigate a reasonable reaction mechanism.

引用

页码：1283 / 1288

页数：6

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