Pathological Roles for Endothelial Colony-Forming Cells in Neonatal and Adult Lung Disease

被引：3

作者：

Robertson, Jason O. ^{[1
]}

Erzurum, Serpil C. ^{[2
]}

Asosingh, Kewal ^{[2
]}

机构：

[1] Cleveland Clin Childrens, Dept Pediat Surg, Cleveland, OH USA

[2] Cleveland Clin, Dept Inflammat & Immun, Lerner Res Inst, Cleveland, OH 44195 USA

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2023年 / 68卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ECFCs; bronchopulmonary dysplasia; congenital diaphragmatic hernia; pulmonary artery hypertension; pulmonary fibrosis; PROGENITOR CELLS; PERIPHERAL-BLOOD; PRETERM INFANTS; FLOW-CYTOMETRY; COPD PATIENTS; DNA-DAMAGE; DYSFUNCTION; IDENTIFICATION; ANGIOGENESIS; HIERARCHY;

D O I：

10.1165/rcmb.2022-0318PS

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial colony-forming cells (ECFCs) are vascular resident and circulating endothelial cell subtypes with potent angiogenic capacity, a hierarchy of single-cell clonogenic potentials, and the ability to participate in de novo blood vessel formation and endothelial repair. Existing literature regarding ECFCs in neonatal and adult pulmonary diseases is confounded by the study of ambiguously defined "endothelial progenitor cells," which are often not true ECFCs. This review contrasts adult and fetal ECFCs, discusses the effect of prematurity on ECFCs, and examines their different pathological roles in neonatal and adult pulmonary diseases, such as bronchopulmonary dysplasia, congenital diaphragmatic hernia, pulmonary artery hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease. Therapeutic potential is also discussed in light of available preclinical data.

引用

页码：13 / 22

页数：10

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