Exploring Molecular Complexity by N-Heterocyclic Carbene Organocatalysis: New Activation and Reaction Diversity

被引：18

作者：

Liu, Yonggui ^{[1
]}

Wang, Yanyan ^{[1
]}

Wu, Xingxing ^{[1
]}

Chi, Yonggui Robin ^{[1
,2
]}

机构：

[1] Guizhou Univ, Lab Breeding Base Green Pesticide & Agr Bioengn, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

CHEMICAL RECORD | 2023年 / 23卷 / 07期

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

N-Heterocyclic Carbene; Organocatalysis; Asymmetric catalysis; NHC-bound intermediates; Molecular complexity; LUMO ACTIVATION; BETA-HYDROXYLATION; PHOSPHORUS LIGANDS; CARBOXYLIC ESTERS; CATALYSIS; ACCESS; ACID; FERROCENE; DESYMMETRIZATION; ALKYLATION;

D O I：

10.1002/tcr.202200219

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of catalytic synthetic approaches towards molecular complexity from simple materials continues to be an ultimate goal in synthetic chemistry. Over the past decades, N-heterocyclic carbene (NHC) organocatalysis has been extensively investigated to provide opportunities for a vast number of novel chemical transformations. Various activation modes and reactive intermediates enabled by NHC small-molecule catalysts, such as Breslow intermediates, (homo)enolates, acyl azoliums and their derived unsaturated azoliums exhibit great potential in the construction of complicated skeletons. This personal account will summarize our group's recent work in the exploration of new activation modes of NHC catalysis towards molecular complexity with a focus on the development and applications of NHC to achieve diversity and enantioselectivity in the preparation of functional molecules.

引用

页数：18

共 162 条

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