An unclear role for the GLP-1 metabolite GLP-1(9-36) in human islet physiology

被引:2
作者
Matveyenko, Aleksey [1 ]
Vella, Adrian [2 ]
机构
[1] Mayo Clin, Coll Med, Dept Physiol & Biomed Engn, Rochester, MN USA
[2] Mayo Clin, Coll Med, Div Endocrinol Diabet & Metab, Rochester, MN 55905 USA
基金
美国国家卫生研究院;
关键词
Alpha cell function; Beta cell function; Dipeptidyl peptidase 4; Endogenous glucose production; Glucagon-like peptide 1; Glucagon suppression; Insulin secretion; GLUCAGON;
D O I
10.1007/s00125-024-06141-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1444 / 1445
页数:2
相关论文
共 50 条
  • [1] An unclear role for the GLP-1 metabolite GLP-1(9-36) in human islet physiology. Reply to Matveyenko A, Vella A [letter]
    Gandasi, Nikhil R.
    Rorsman, Patrik
    DIABETOLOGIA, 2024, 67 (07) : 1446 - 1447
  • [2] GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
    Gandasi, Nikhil R.
    Gao, Rui
    Kothegala, Lakshmi
    Pearce, Abigail
    Santos, Cristiano
    Acreman, Samuel
    Basco, Davide
    Benrick, Anna
    Chibalina, Margarita V.
    Clark, Anne
    Guida, Claudia
    Harris, Matthew
    Johnson, Paul R. V.
    Knudsen, Jakob G.
    Ma, Jinfang
    Miranda, Caroline
    Shigeto, Makoto
    Tarasov, Andrei I.
    Yeung, Ho Yan
    Thorens, Bernard
    Asterholm, Ingrid W.
    Zhang, Quan
    Ramracheya, Reshma
    Ladds, Graham
    Rorsman, Patrik
    DIABETOLOGIA, 2024, 67 (03) : 528 - 546
  • [3] GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
    Nikhil R. Gandasi
    Rui Gao
    Lakshmi Kothegala
    Abigail Pearce
    Cristiano Santos
    Samuel Acreman
    Davide Basco
    Anna Benrick
    Margarita V. Chibalina
    Anne Clark
    Claudia Guida
    Matthew Harris
    Paul R. V. Johnson
    Jakob G. Knudsen
    Jinfang Ma
    Caroline Miranda
    Makoto Shigeto
    Andrei I. Tarasov
    Ho Yan Yeung
    Bernard Thorens
    Ingrid W. Asterholm
    Quan Zhang
    Reshma Ramracheya
    Graham Ladds
    Patrik Rorsman
    Diabetologia, 2024, 67 : 528 - 546
  • [4] Possible involvement of GLP-1(9-36) in the regional haemodynamic effects of GLP-1(7-36) in conscious rats
    Gardiner, S. M.
    March, J. E.
    Kemp, P. A.
    Bennett, T.
    Baker, D. J.
    BRITISH JOURNAL OF PHARMACOLOGY, 2010, 161 (01) : 92 - 102
  • [5] PHYSIOLOGY OF PROGLUCAGON PEPTIDES: ROLE OF GLUCAGON AND GLP-1 IN HEALTH AND DISEASE
    Sandoval, Darleen A.
    D'Alessio, David A.
    PHYSIOLOGICAL REVIEWS, 2015, 95 (02) : 513 - 548
  • [6] GLP-1 Receptor Blockade Reduces Stimulated Insulin Secretion in Fasted Subjects With Low Circulating GLP-1
    Gray, Sarah M.
    Hoselton, Andrew L.
    Krishna, Radha
    Slentz, Cris A.
    D'Alessio, David A.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 107 (09) : 2500 - 2510
  • [7] GLP-1, GIP/GLP-1, and GCGR/GLP-1 receptor agonists: Novel therapeutic agents for metabolic dysfunction-associated steatohepatitis
    Singh, Anmol
    Sohal, Aalam
    Batta, Akash
    WORLD JOURNAL OF GASTROENTEROLOGY, 2024, 30 (48) : 5205 - 5211
  • [8] Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment
    Trapp, Stefan
    Brierley, Daniel, I
    BRITISH JOURNAL OF PHARMACOLOGY, 2022, 179 (04) : 557 - 570
  • [9] Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1
    Hager, Marlies V.
    Clydesdale, Lachlan
    Gellman, Samuel H.
    Sexton, Patrick M.
    Wootten, Denise
    BIOCHEMICAL PHARMACOLOGY, 2017, 136 : 99 - 108
  • [10] THE ROLE OF GLP-1 IN NEURONAL ACTIVITY AND NEURODEGENERATION
    Hoelscher, Christian
    VITAMINS AND HORMONES: INCRETINS AND INSULIN SECRETION, 2010, 84 : 331 - 354