A surgical mouse model of neonatal right ventricular outflow tract obstruction by pulmonary artery banding

被引：2
|
作者：
Li, Debao [1 ,2 ]
Hong, Haifa [3 ]
Li, Minghui [4 ]
Xu, Xiuxia [5 ]
Wang, Shoubao [6 ]
Xiao, Yingying [3 ]
Zheng, Sixie [1 ]
Wang, Zheng [1 ]
Yan, Yi [7 ,8 ,9 ,10 ]
Chen, Hao [1 ,8 ,9 ,10 ]
Zhou, Chunxia [1 ]
Zhang, Hao [1 ,7 ,8 ,9 ,10 ,11 ,13 ]
Sun, Qi [1 ,14 ]
Ye, Lincai [1 ,11 ,12 ,15 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Thorac & Cardiovasc Surg, Shanghai, Peoples R China
[2] Fudan Univ, Natl Childrens Med Ctr, Dept Pediat Surg, Childrens Hosp, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Sch Med, Dept Thorac & Cardiovasc Surg, Shanghai, Peoples R China
[4] Nanjing Med Univ, Dept Cardiovasc Surg, Affiliated Hosp 1, Nanjing, Peoples R China
[5] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Radiol, Huangpu Branch,Sch Med, Shanghai, Peoples R China
[6] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast Surg, Shanghai, Peoples R China
[7] Shanghai Jiao Tong Univ, Shanghai Clin Res Ctr Rare Pediat Dis, Shanghai Childrens Med Ctr, Sch Med, Shanghai, Peoples R China
[8] Shanghai Jiao Tong Univ, Shanghai Res Ctr Pediat Cardiovasc Dis, Shanghai Childrens Med Ctr, Sch Med, Shanghai, Peoples R China
[9] Shanghai Jiao Tong Univ, Heart Ctr, Sch Med, Shanghai Childrens Med Ctr, Shanghai, Peoples R China
[10] Shanghai Jiao Tong Univ, Shanghai Inst Pediat Congenital Heart Dis, Shanghai Childrens Med Ctr, Sch Med, Shanghai, Peoples R China
[11] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai Inst Pediat Congenital Heart Dis, Shanghai, Peoples R China
[12] Shanghai Jiao Tong Univ, Inst Pediat Translat Med, Shanghai Childrens Med Ctr, Sch Med, Shanghai, Peoples R China
[13] Shanghai Jiao Tong Univ, Shanghai Inst Pediat Congenital Heart Dis, Shanghai Childrens Med Ctr, Sch Med, 1678 Dongfang Rd, Shanghai 200127, Peoples R China
[14] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Thorac & Cardiovasc Surg, 1678 Dongfang Rd, Shanghai 200127, Peoples R China
[15] Shanghai Jiao Tong Univ, Inst Pediat Translat Med, Shanghai Childrens Med Ctr, Sch Med, 1678 Dongfang Rd, Shanghai 200127, Peoples R China
来源：
JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2024年 / 43卷 / 03期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Tetralogy of Fallot; pulmonary hypertension; right ventricle; congenital heart disease; cardiomyocyte proliferation; pressure overload; pulmonary dysplasia; CONGENITAL HEART-DISEASE; STENOSIS;
D O I：
10.1016/j.healun.2023.10.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BACKGROUD: Diseased animal models play an extremely important role in preclinical research. Lacking the corresponding animal models, many basic research studies cannot be carried out, and the conclusions obtained are incomplete or even incorrect. Right ventricular (RV) outflow tract (RVOT) obstruction leads to RV pressure overload (PO) and reduced pulmonary blood flow (RPF), which are 2 of the most important pathophysiological characteristics in pediatric cardiovascular diseases and seriously affect the survival rate and long-term quality of life of many children. Due to the lack of a neonatal mouse model for RVOT obstruction, it is largely unknown how RV PO and RPF regulate postnatal RV and pulmonary development. The aim of this study was to construct a neonatal RVOT obstruction mouse model. METHODS AND RESULTS: Here, we first introduced a neonatal mouse model of RVOT obstruction by pulmonary artery banding (PAB) on postnatal day 1. PAB induced neonatal RVOT obstruction, RV PO, and RPF. Neonatal RV PO induced cardiomyocyte proliferation, and neonatal RPF induced pulmonary dysplasia, the 2 features that are not observed in adult RVOT obstruction. As a result, PAB neonates exhibited overall developmental dysplasia, a sign similar to that of children with RVOT obstruction. CONCLUSIONS: Because many pediatric cardiovascular diseases are associated with RV PO and RPF, the introduction of a neonatal mouse model of RVOT obstruction may greatly enhance our understanding of these diseases and eventually improve or save the lives of many children. J Heart Lung Transplant 2024;43:496-507 (c) 2023 International Society for Heart and Lung Transplantation. All rights reserved.
引用
收藏
页码：496 / 507
页数：12
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