Serum biomarkers associated with aging and neurodegeneration in common marmosets (Callithrix jacchus)

被引：1

作者：

Phillips, Kimberley A. ^{[1
,2
]}

Lopez, Matthew ^{[1
,2
]}

Bartling-John, Evelyn ^{[1
]}

Meredith, Reagan ^{[3
]}

Buteau, Anna ^{[1
]}

Alvarez, Addaline ^{[2
]}

Ross, Corinna N. ^{[2
,3
]}

机构：

[1] Trinity Univ, Dept Psychol, San Antonio, TX 78212 USA

[2] Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX 78227 USA

[3] Texas Biomed Res Inst, San Antonio, TX USA

来源：

NEUROSCIENCE LETTERS | 2024年 / 819卷

基金：

美国国家卫生研究院;

关键词：

Common marmoset; Biomarkers; Neurodegeneration; Neurofilament light; UCH-L1; GFAP; Tau;

D O I：

10.1016/j.neulet.2023.137569

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The common marmoset (Callithrix jacchus), a small South American monkey, is an important nonhuman primate model in the study of aging and age-related neurodegenerative disease, including Alzheimer's disease, Parkin-son's disease, and related dementias. Thorough characterization of the wild type marmoset brain aging model, including biomarkers of aging and neural degeneration, will further the marmoset's utility in translational research. We measured serum concentration of four key biomarkers of neural degeneration [total tau (T-tau), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and ubiquitin C-terminal hydrolase-L1 (UCH-L1)] via single molecule array from 24 marmosets (female n = 13, male n = 11) ranging in age from 1.3 to 18.7 years. Aged marmosets (>7 years) had significantly higher GFAP, NfL, UCH-L1, and T-tau than adult marmosets. Sex differences were not detected for any of these biomarker concentrations. These data provide an important initial range of reference values for GFAP, NfL, T-tau, and UCH-L1 to evaluate aging and neural health in marmosets, as well as evaluation of therapeutics in clinical models of disease.

引用

页数：5

共 50 条

[41] Understanding visual access in common marmosets, Callithrix jacchus:: perspective taking or behaviour reading? [J].

Burkart, Judith Maria ;

Heschl, Adolf .

ANIMAL BEHAVIOUR, 2007, 73 :457-469

[42] Neonatal behavioral scoring of common marmosets (Callithrix jacchus):: relation to physical condition and survival [J].

Tardif, SD ;

Layne, DG ;

Cancino, L ;

Smucny, DA .

JOURNAL OF MEDICAL PRIMATOLOGY, 2002, 31 (03) :147-151

[43] Effect of Nest Box Availability on the Circadian Activity Rhythm of Common Marmosets (Callithrix jacchus) [J].

Goncalves, Fabiana B. ;

Belisio, Aline S. ;

Azevedo, Carolina V. M. .

FOLIA PRIMATOLOGICA, 2009, 80 (03) :175-188

[44] Trade-offs between social learning and individual innovativeness in common marmosets, Callithrix jacchus [J].

Burkart, Judith M. ;

Strasser, Andrea ;

Foglia, Maria .

ANIMAL BEHAVIOUR, 2009, 77 (05) :1291-1301

[45] Assessment of the Parameters of Adaptive Cell-Mediated Immunity in Naive Common Marmosets (Callithrix jacchus) [J].

Gordeychuk, I. V. ;

Tukhvatulin, A. I. ;

Petkov, S. P. ;

Abakumov, M. A. ;

Gulyaev, S. A. ;

Tukhvatulina, N. M. ;

Gulyaeva, T. V. ;

Mikhaylov, M. I. ;

Logunov, D. Y. ;

Isaguliants, M. G. .

ACTA NATURAE, 2018, 10 (04) :63-69

[46] Development of stereotaxic recording system for awake marmosets (Callithrix jacchus) [J].

Wakabayashi, Masahiro ;

Koketsu, Daisuke ;

Kondo, Hideki ;

Sato, Shigeki ;

Ohara, Kiichi ;

Polyakova, Zlata ;

Chiken, Satomi ;

Hatanaka, Nobuhiko ;

Nambu, Atsushi .

NEUROSCIENCE RESEARCH, 2018, 135 :37-45

[47] Development of infant common marmosets' (Callithrix jacchus) preference for their parents over adults from another group [J].

Saito, Atsuko ;

Izumi, Akihiro ;

Nakamura, Katsuki .

PRIMATES, 2011, 52 (01) :43-50

[48] Determination of Minimum Alveolar Concentrations of Isoflurane and Effective Plasma Concentration of Propofol in Common Marmosets (Callithrix jacchus) [J].

Muta, Kanako ;

Koizumi, Makoto ;

Miyabe-Nishiwaki, Takako ;

Sotomaru, Yusuke ;

Nobukiyo, Asako ;

Ohta, Hiroki ;

Okano, Hirotaka James ;

Kamata, Masatoshi ;

Nagakubo, Dai ;

Nishimura, Ryohei .

JOURNAL OF MEDICAL PRIMATOLOGY, 2025, 54 (02)

[49] Object permanence in adult common marmosets (Callithrix jacchus): not everything is an “A-not-B” error that seems to be one [J].

Anna Kis ;

Márta Gácsi ;

Friederike Range ;

Zsófia Virányi .

Animal Cognition, 2012, 15 :97-105

[50] Social condition modulates neuroendocrine response to sexual sensory stimuli in male common marmosets, Callithrix jacchus [J].

Ziegler, T. ;

Schultz-Darken, N. ;

Scott, J. ;

Snowdon, C. ;

Ferris, C. .

FOLIA PRIMATOLOGICA, 2004, 75 :223-223

← 1 2 3 4 5 →