Cytogenetics in the management of acute myeloid leukemia and histiocytic/dendritic cell neoplasms: Guidelines from the Groupe Francophone de Cytog<acute accent>en<acute accent>etique H<acute accent>ematologique (GFCH)

被引：4

作者：

Bidet, Audrey ^{[1
]}

Quessada, Julie ^{[2
,3
]}

Cuccuini, Wendy ^{[4
]}

Decamp, Matthieu ^{[5
]}

Lafage-Pochitaloff, Marina ^{[2
]}

Luquet, Isabelle ^{[6
]}

Lefebvre, Christine ^{[7
]}

Tueur, Giulia ^{[8
]}

机构：

[1] CHU Bordeaux, Lab Hematol Biol, Ave Magellan, F-33600 Pessac, France

[2] Aix Marseille Univ, Hop Enfants Timone, Assistance Pub Hop Marseille APHM, Fac Med,Lab Cytogenet Hematol, F-13005 Marseille, France

[3] Aix Marseille Univ, CIML, CNRS, INSERM, F-13009 Marseille, France

[4] Hop St Louis, Assistance Publ Hop Paris AP HP, Lab Hematol, Paris, France

[5] CHU Caen Normandie, Serv Neurol, F-14000 Caen, France

[6] CHU Toulouse, Lab Hematol, Site IUCT O, Toulouse, France

[7] CHU Grenoble Alpes, Serv Hematol Biol, Unite Genet Hemopathies, Grenoble, France

[8] CHU Avicenne, AP HP, Lab Hematol, Bobigny, France

来源：

CURRENT RESEARCH IN TRANSLATIONAL MEDICINE | 2023年 / 71卷 / 04期

关键词：

Acute myeloid leukemia; Histiocytic/dendritic cell neoplasms; Cytogenetic abnormalities; Prognosis; ACUTE MEGAKARYOBLASTIC LEUKEMIA; CORE-BINDING-FACTOR; HEALTH-ORGANIZATION CLASSIFICATION; INDIVIDUAL PATIENT DATA; MONOSOMAL KARYOTYPE; COMPLEX KARYOTYPE; POOR-PROGNOSIS; ADULT PATIENTS; HIGH-RISK; AML;

D O I：

10.1016/j.retram.2023.103421

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Genetic data are becoming increasingly essential in the management of hematological neoplasms as shown by two classifications published in 2022: the 5th edition of the World Health Organization Classification of Hematolymphoid Tumours and the International Consensus Classification of Myeloid Neoplasms and Acute Leukemias. Genetic data are particularly important for acute myeloid leukemias (AMLs) because their boundaries with myelodysplastic neoplasms seem to be gradually blurring. The first objective of this review is to present the latest updates on the most common cytogenetic abnormalities in AMLs while highlighting the pitfalls and difficulties that can be encountered in the event of cryptic or difficult-to-detect karyotype abnormalities. The second objective is to enhance the role of cytogenetics among all the new technologies available in 2023 for the diagnosis and management of AML.

引用

页数：13

共 112 条

[1] TET2 Mutations, Myelodysplastic Features, and A Distinct Immunoprofile Characterize Blastic Plasmacytoid Dendritic Cell Neoplasm in the Bone Marrow [J].

Alayed, Khaled ;

Patel, Keyur P. ;

Konoplev, Sergej ;

Singh, Rajesh R. ;

Routbort, Mark J. ;

Reddy, Neelima ;

Pemmaraju, Naveen ;

Zhang, Liping ;

Al Shaikh, Abdulaziz ;

Aladily, Tariq N. ;

Jain, Nitin ;

Luthra, Rajyalakshmi ;

Medeiros, L. Jeffrey ;

Khoury, Joseph D. .

AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (12) :1055-1061

[2] Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts [J].

Angenendt, Linus ;

Roellig, Christoph ;

Montesinos, Pau ;

Martinez-Cuadron, David ;

Barragan, Eva ;

Garcia, Raimundo ;

Botella, Carmen ;

Martinez, Pilar ;

Ravandi, Farhad ;

Kadia, Tapan ;

Kantarjian, Hagop M. ;

Cortes, Jorge ;

Juliusson, Gunnar ;

Lazarevic, Vladimir ;

Hoglund, Martin ;

Lehmann, Soren ;

Recher, Christian ;

Pigneux, Arnaud ;

Bertoli, Sarah ;

Dumas, Pierre-Yves ;

Dombret, Herve ;

Preudhomme, Claude ;

Micol, Jean-Baptiste ;

Terre, Christine ;

Racil, Zdenek ;

Novak, Jan ;

Zak, Pavel ;

Wei, Andrew H. ;

Tiong, Ing S. ;

Wall, Meaghan ;

Estey, Elihu ;

Shaw, Carole ;

Exeler, Rita ;

Wagenfuehr, Lisa ;

Stoelzel, Friedrich ;

Thiede, Christian ;

Stelljes, Matthias ;

Lenz, Georg ;

Mikesch, Jan-Henrik ;

Serve, Hubert ;

Ehninger, Gerhard ;

Berdel, Wolfgang E. ;

Kramer, Michael ;

Krug, Utz ;

Schliemann, Christoph .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (29) :2632-+

[3] International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert P. ;

Borowitz, Michael J. ;

Calvo, Katherine R. ;

Kvasnicka, Hans-Michael ;

Wang, Sa A. ;

Bagg, Adam ;

Barbui, Tiziano ;

Branford, Susan ;

Bueso-Ramos, Carlos E. ;

Cortes, Jorge E. ;

Dal Cin, Paola ;

DiNardo, Courtney D. ;

Dombret, Herve ;

Duncavage, Eric J. ;

Ebert, Benjamin L. ;

Estey, Elihu H. ;

Facchetti, Fabio ;

Foucar, Kathryn ;

Gangat, Naseema ;

Gianelli, Umberto ;

Godley, Lucy A. ;

Gokbuget, Nicola ;

Gotlib, Jason ;

Hellstrom-Lindberg, Eva ;

Hobbs, Gabriela S. ;

Hoffman, Ronald ;

Jabbour, Elias J. ;

Kiladjian, Jean-Jacques ;

Larson, Richard A. ;

Le Beau, Michelle M. ;

Loh, Mignon L. -C. ;

Lowenberg, Bob ;

Macintyre, Elizabeth ;

Malcovati, Luca ;

Mullighan, Charles G. ;

Niemeyer, Charlotte ;

Odenike, Olatoyosi M. ;

Ogawa, Seishi ;

Orfao, Alberto ;

Papaemmanuil, Elli ;

Passamonti, Francesco ;

Porkka, Kimmo ;

Pui, Ching-Hon ;

Radich, Jerald P. ;

Reiter, Andreas ;

Rozman, Maria ;

Rudelius, Martina ;

Savona, Michael R. .

BLOOD, 2022, 140 (11) :1200-1228

[4] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert ;

Thiele, Jurgen ;

Borowitz, Michael J. ;

Le Beau, Michelle M. ;

Bloomfield, Clara D. ;

Cazzola, Mario ;

Vardiman, James W. .

BLOOD, 2016, 127 (20) :2391-2405

[5] AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features and unfavorable outcome [J].

Assaf, Nada ;

Lefebvre, Christine ;

Raggueneau, Victoria ;

Guignedoux, Geoffroy ;

Marceau-Renaut, Alice ;

Chevalier, Simon ;

Tondeur, Sylvie ;

Bories, Dominique ;

Benramdane, Riad ;

Rousselot, Philippe ;

Terre, Christine .

HEMATOLOGY, 2022, 27 (01) :636-641

[6] Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study [J].

Balgobind, Brian V. ;

Raimondi, Susana C. ;

Harbott, Jochen ;

Zimmermann, Martin ;

Alonzo, Todd A. ;

Auvrignon, Anne ;

Beverloo, H. Berna ;

Chang, Myron ;

Creutzig, Ursula ;

Dworzak, Michael N. ;

Forestier, Erik ;

Gibson, Brenda ;

Hasle, Henrik ;

Harrison, Christine J. ;

Heerema, Nyla A. ;

Kaspers, Gertjan J. L. ;

Leszl, Anna ;

Litvinko, Nathalia ;

Lo Nigro, Luca ;

Morimoto, Akira ;

Perot, Christine ;

Pieters, Rob ;

Reinhardt, Dirk ;

Rubnitz, Jeffrey E. ;

Smith, Franklin O. ;

Stary, Jan ;

Stasevich, Irina ;

Strehl, Sabine ;

Taga, Takashi ;

Tomizawa, Daisuke ;

Webb, David ;

Zemanova, Zuzana ;

Zwaan, C. Michel ;

van den Heuvel-Eibrink, Marry M. .

BLOOD, 2009, 114 (12) :2489-2496

[7] 8q24/&ITMYC&IT rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms [J].

Boddu, Prajwal C. ;

Wang, Sa A. ;

Pemmaraju, Naveen ;

Tang, Zhenya ;

Hu, Shimin ;

Li, Shaoying ;

Xu, Jie ;

Medeiros, L. Jeffrey ;

Tang, Guilin .

LEUKEMIA RESEARCH, 2018, 66 :73-78

[8] Monosomal karyotype in acute myeloid leukemia:: A better indicator of poor prognosis than a complex karyotype [J].

Breems, Dimitri A. ;

Van Putten, Wim L. J. ;

De Greef, Georgine E. ;

Van Zelderen-Bhola, Shama L. ;

Gerssen-Schoorl, Klasien B. J. ;

Mellink, Clemens H. M. ;

Nieuwint, Aggie ;

Jotterand, Martine ;

Hagemeijer, Anne ;

Beverloo, H. Berna ;

Lowenberg, Bob .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (29) :4791-4797

[9] A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay [J].

Brown, J ;

Jawad, M ;

Twigg, SRF ;

Saracoglu, K ;

Sauerbrey, A ;

Thomas, AE ;

Eils, R ;

Harbott, J ;

Kearney, L .

BLOOD, 2002, 99 (07) :2526-2531

[10] Genomics of Acute Myeloid Leukemia Diagnosis and Pathways [J].

Bullinger, Lars ;

Doehner, Konstanze ;

Doehner, Hartmut .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (09) :934-946

← 1 2 3 4 5 6 7 8 9 10 →