MicroRNAs Derived from Extracellular Vesicles: Keys to Understanding SARS-CoV-2 Vaccination Response in Cancer Patients?

被引：2
作者：
Almeida, Beatriz [1 ,2 ,3 ]
Dias, Tania R. [1 ,2 ,4 ]
Teixeira, Ana Luisa [1 ,2 ]
Dias, Francisca [1 ,2 ]
Medeiros, Rui [1 ,2 ,4 ,5 ,6 ,7 ]
机构：
[1] Porto Comprehens Canc Ctr Porto CCC, Mol Oncol & Viral Pathol Grp, Res Ctr IPO Porto CI IPOP, P-4200072 Porto, Portugal
[2] Porto Comprehens Canc Ctr Porto CCC, RISE CI IPOP Hlth Res Network, Portuguese Oncol Inst Porto IPO Porto, P-4200072 Porto, Portugal
[3] Univ Aveiro, Dept Chem, Campus Univ Santiago, P-3810193 Aveiro, Portugal
[4] Univ Porto, Abel Salazar Inst Biomed Sci ICBAS, P-4050513 Porto, Portugal
[5] Porto Comprehens Canc Ctr Porto CCC, Portuguese Oncol Inst Porto IPO Porto, Lab Med, Clin Pathol Dept, P-4200072 Porto, Portugal
[6] Fernando Pessoa Univ UFP, Biomed Res Ctr CEBIMED, Res Inovat & Dev Inst FP I3ID, Fac Hlth Sci, P-4249004 Porto, Portugal
[7] Portuguese League Canc Northern Branch LPCC NRN, Res Dept, P-4200172 Porto, Portugal
来源：
CANCERS | 2023年 / 15卷 / 16期
关键词：
extracellular vesicles; microRNAs; SARS-CoV-2; MESSENGER-RNA VACCINE; BREAST-CANCER; COVID-19; MIR-145-5P;
D O I：
10.3390/cancers15164017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provoked a global pandemic identified as coronavirus disease (COVID-19), with millions of deaths worldwide. However, several important questions regarding its impact on public health remain unanswered, such as the impact of vaccination on vulnerable subpopulations such as cancer patients. Cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion, being manifested in most immunocompromised individuals. This strong immunosuppression can lead to a dysfunctional antiviral response to natural viral infection and compromised vaccination response. Extracellular vesicles (EVs) are membrane-bound vesicles released from cells that are involved in intercellular communication. EVs carry various molecules including microRNAs that play a crucial role in COVID-19 pathophysiology, influencing cellular responses. This review summarizes the state of the art concerning the role of EV-derived miRNAs in COVID-19 infection and their potential use as prognosis biomarkers for vaccination response in cancer patients.
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页数：15
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