CDK12/13 inhibition in ovarian cancer cell lines

被引：0
|
作者：
Fiegl, H. [1 ]
Hovdar, L. [1 ]
Handle, F. [2 ]
Santer, F. [3 ]
Tsibulak, I [1 ]
Wieser, V [1 ]
Ausserlechner, M. J. [4 ]
Schnaiter, S. [5 ]
Zeimet, A. G. [1 ]
Marth, C. [1 ]
机构：
[1] Med Univ Innsbruck, Dept Obstet & Gynecol, Innsbruck, Austria
[2] Med Univ Innsbruck, Inst Pathol Neuropathol & Mol Pathol, Innsbruck, Austria
[3] Med Univ Innsbruck, Dept Urol, Innsbruck, Austria
[4] Med Univ Innsbruck, Dept Pediat 1, Innsbruck, Austria
[5] Med Univ Innsbruck, Inst Human Genet, Innsbruck, Austria
来源：
GEBURTSHILFE UND FRAUENHEILKUNDE | 2023年 / 83卷 / 04期
关键词：
REPAIR;
D O I：
10.1055/s-0043-1766400
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
009
引用
收藏
页码：5 / 5
页数：1
相关论文
共 50 条
  • [31] Ovarian carcinoma CDK12 mutations misregulate DNA repair genes via deficient formation and function of the Cdk12/CycK complex
    Ekumi, Kingsley M.
    Paculova, Hana
    Pospichalova, Vendula
    Bosken, Christian A.
    Bryja, Vitezslav
    Geyer, Matthias
    Blazek, Dalibor
    Barboric, Matjaz
    CLINICAL CANCER RESEARCH, 2015, 21
  • [32] CDK12/13: A Promising New Therapeutic Target in ALL
    Dudkiewicz, Julia
    Garbicz, Filip
    Wlodarski, Pawel Krzysztof
    BLOOD, 2023, 142
  • [33] CDK12 inhibition induces mitotic arrest in pancreatic cancer, triggering mitotic cell death and genome instability
    Iwadate, Dosuke
    Yamamoto, Keisuke
    Fujishiro, Mitsuhiro
    CANCER SCIENCE, 2025, 116 : 1405 - 1405
  • [34] CDK12 Deficiency and the Immune Microenvironment in Prostate Cancer
    Lotan, Tamara L.
    Antonarakis, Emmanuel S.
    CLINICAL CANCER RESEARCH, 2021, 27 (02) : 380 - 382
  • [35] Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
    Ekumi, Kingsley M.
    Paculova, Hana
    Lenasi, Tina
    Pospichalova, Vendula
    Boesken, Christian A.
    Rybarikova, Jana
    Bryja, Vitezslav
    Geyer, Matthias
    Blazek, Dalibor
    Barboric, Matjaz
    NUCLEIC ACIDS RESEARCH, 2015, 43 (05) : 2575 - 2589
  • [36] Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
    Chang, Yu
    Wang, Xiaoju
    Yang, Jianzhang
    Tien, Jean Ching-Yi
    Mannan, Rahul
    Cruz, Gabriel
    Zhang, Yuping
    Vo, Josh N.
    Magnuson, Brian
    Mahapatra, Somnath
    Cho, Hanbyul
    Dhanasekaran, Saravana Mohan
    Wang, Cynthia
    Wang, Zhen
    Zhou, Licheng
    Zhou, Kaijie
    Zhou, Yang
    Zhang, Pujuan
    Huang, Weixue
    Xiao, Lanbo
    Liu, Weihuang Raymond
    Hamadeh, Rudana
    Su, Fengyun
    Wang, Rui
    Miner, Stephanie J.
    Cao, Xuhong
    Cheng, Yunhui
    Mehra, Rohit
    Ding, Ke
    Chinnaiyan, Arul M.
    CELL REPORTS, 2024, 5 (10):
  • [37] EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
    Iniguez, Amanda Balboni
    Stolte, Bjoern
    Wang, Emily Jue
    Conway, Amy Saur
    Alexe, Gabriela
    Dharia, Neekesh V.
    Kwiatkowski, Nicholas
    Zhang, Tinghu
    Abraham, Brian J.
    Mora, Jaume
    Kalev, Peter
    Leggett, Alan
    Chowdhury, Dipanjan
    Benes, Cyril H.
    Young, Richard A.
    Gray, Nathanael S.
    Stegmaier, Kimberly
    CANCER CELL, 2018, 33 (02) : 202 - +
  • [38] Targeting chemoresistant ovarian malignancies to cytostatic drugs and PARP inhibitors by inhibition of CDK12 kinase activity.
    Kohoutek, Jiri
    Svoboda, Marek
    Vrabel, David
    Paculova, Hana
    Dzimkova, Marta
    CLINICAL CANCER RESEARCH, 2016, 22
  • [39] Discovery of a highly potent and selective dual PROTAC degrader of CDK12 and CDK13
    Chang, Yu
    Yang, Jianzhang
    Tien, Jean Ching-Yi
    Wang, Zhen
    Zhou, Yang
    Zhang, Pujuan
    Huang, Weixue
    Vo, Josh
    Apel, Ingrid J.
    Wang, Cynthia
    Zeng, Victoria Zhixuan
    Cheng, Yunhui
    Li, Shuqin
    Wang, George Xiaoju
    Ding, Ke
    Chinnaiyan, Arul M.
    CANCER RESEARCH, 2023, 83 (07)
  • [40] Synthetic lethality of CDK12 inhibition in tumors with EWS/FLI rearrangements
    Balboni, Amanda L.
    Stolte, Bjorn
    Conway, Amy Saur
    Alexe, Gabriela
    Wang, Emily Jue
    Kwiatkowski, Nicholas
    Zhang, Tinghu
    Abraham, Brian J.
    Kalev, Peter
    Chowdhury, Dipanjan
    Benes, Cyril H.
    Young, Richard A.
    Gray, Nathanael S.
    Stegmaier, Kimberly
    CANCER RESEARCH, 2017, 77
12345