Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases

被引:13
|
作者
Mostafa, Mahmoud [1 ]
Al Fatease, Adel [2 ]
Alany, Raid G. [3 ,4 ]
Abdelkader, Hamdy [2 ]
机构
[1] Minia Univ, Fac Pharm, Dept Pharmaceut, Al Minya 61519, Egypt
[2] King Khalid Univ, Coll Pharm, Dept Pharmaceut, Abha 62223, Saudi Arabia
[3] Kingston Univ London, Sch Pharm, Kingston Upon Tames KT1 2EE, England
[4] Univ Auckland, Sch Pharm, Auckland 1010, New Zealand
关键词
chronic eye diseases; inserts; implants; ocular delivery; IN-VITRO CHARACTERIZATION; VIVO PHARMACODYNAMIC EVALUATION; NANOSTRUCTURED LIPID CARRIERS; DRY-EYE; SUSTAINED-RELEASE; EX-VIVO; MACULAR DEGENERATION; OPHTHALMIC DELIVERY; HYALURONIC-ACID; AQUEOUS-HUMOR;
D O I
10.3390/pharmaceutics15061746
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Chronic ocular diseases can seriously impact the eyes and could potentially result in blindness or serious vision loss. According to the most recent data from the WHO, there are more than 2 billion visually impaired people in the world. Therefore, it is pivotal to develop more sophisticated, long-acting drug delivery systems/devices to treat chronic eye conditions. This review covers several drug delivery nanocarriers that can control chronic eye disorders non-invasively. However, most of the developed nanocarriers are still in preclinical or clinical stages. Long-acting drug delivery systems, such as inserts and implants, constitute the majority of the clinically used methods for the treatment of chronic eye diseases due to their steady state release, persistent therapeutic activity, and ability to bypass most ocular barriers. However, implants are considered invasive drug delivery technologies, especially those that are nonbiodegradable. Furthermore, in vitro characterization approaches, although useful, are limited in mimicking or truly representing the in vivo environment. This review focuses on long-acting drug delivery systems (LADDS), particularly implantable drug delivery systems (IDDS), their formulation, methods of characterization, and clinical application for the treatment of eye diseases.
引用
收藏
页数:50
相关论文
共 50 条
  • [21] Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases
    Bisht, Rohit
    Mandal, Abhirup
    Jaiswal, Jagdish K.
    Rupenthal, Ilva D.
    WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2018, 10 (02)
  • [22] Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases
    Bao, Qingdong
    Zhang, Xiaoting
    Hao, Zhankun
    Li, Qinghua
    Wu, Fan
    Wang, Kaiyuan
    Li, Yang
    Li, Wenlong
    Gao, Hua
    NANO-MICRO LETTERS, 2024, 16 (01)
  • [23] Innovation in the Development of Synthetic and Natural Ocular Drug Delivery Systems for Eye Diseases Treatment: Focusing on Drug-Loaded Ocular Inserts, Contacts, and Intraocular Lenses
    Pelusi, Letizia
    Mandatori, Domitilla
    Mastropasqua, Leonardo
    Agnifili, Luca
    Allegretti, Marcello
    Nubile, Mario
    Pandolfi, Assunta
    PHARMACEUTICS, 2023, 15 (02)
  • [24] Ocular drug delivery systems:An overview
    Ashaben Patel
    Kishore Cholkar
    Vibhuti Agrahari
    Ashim K Mitra
    World Journal of Pharmacology, 2013, (02) : 47 - 64
  • [25] Nanoceria for ocular diseases: recent advances and future prospects
    Cui, W.
    Wang, Y.
    Luo, C.
    Xu, J.
    Wang, K.
    Han, H.
    Yao, K.
    MATERIALS TODAY NANO, 2022, 18
  • [26] Recent Advancemnts in Biodegradable Ocular Implants
    Mittal, Swati
    Miranda, Oshin
    CURRENT DRUG DELIVERY, 2018, 15 (02) : 144 - 154
  • [27] Topical Advances in Mucoadhesive Ocular Drug Delivery System
    Billowria, Koushal
    Sandhu, Navjot Kaur
    Singh, Baljinder
    CURRENT DRUG DELIVERY, 2023, 20 (08) : 1127 - 1140
  • [28] Controlled and Continuous Release Ocular Drug Delivery Systems: Pros and Cons
    Abdelkader, Hamdy
    Alany, Raid G.
    CURRENT DRUG DELIVERY, 2012, 9 (04) : 421 - 430
  • [29] Strategies to prolong the residence time of drug delivery systems on ocular surface
    Grassiri, Brunella
    Zambito, Ylenia
    Bernkop-Schnurch, Andreas
    ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2021, 288
  • [30] Novel drug delivery systems for ocular therapy: With special reference to liposomal ocular delivery
    Bhattacharjee, Arpita
    Das, Pranab J.
    Adhikari, Piya
    Marbaniang, Daphisha
    Pal, Paulami
    Ray, Subhabrata
    Mazumder, Bhaskar
    EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2019, 29 (01) : 113 - 126