Ultralow Background Near-Infrared Fluorophores with Dual-Channel Intraoperative Imaging Capability

被引：14

作者：

Bao, Kai ^{[1
,2
]}

Tully, Molly ^{[1
,2
]}

Cardenas, Kevin ^{[1
,2
]}

Wang, Haoran ^{[1
,2
]}

Srinivas, Surbhi ^{[1
,2
]}

Rho, Jiyun ^{[1
,2
,3
,4
]}

Jeon, Ok Hwa ^{[3
,4
]}

Dinh, Jason ^{[1
,2
]}

Yokomizo, Shinya ^{[1
,2
]}

McDonnell, Rose ^{[1
,2
]}

Yamashita, Atsushi ^{[1
,2
]}

Kashiwagi, Satoshi ^{[1
,2
]}

Kang, Homan ^{[1
,2
]}

Kim, Hyun Koo ^{[3
,4
]}

Choi, Hak Soo ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02114 USA

[2] Harvard Med Sch, Boston, MA 02114 USA

[3] Korea Univ, Guro Hosp, Coll Med, Dept Biomed Sci, Seoul 08308, South Korea

[4] Korea Univ, Guro Hosp, Coll Med, Dept Thorac & Cardiovasc Surg, Seoul 08308, South Korea

来源：

ADVANCED HEALTHCARE MATERIALS | 2023年 / 12卷 / 12期

关键词：

multispectral imaging; NIR imaging; renal clearance; targeted fluorophores; tumor targeting; GUIDED SURGERY;

D O I：

10.1002/adhm.202203134

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Two of the most pressing challenges facing bioimaging are nonspecific uptake of intravenously administered contrast agents and incomplete elimination of unbound targeted agents from the body. Designing a targeted contrast agent that shows fast clearance from background tissues and eventually the body after complete targeting is key to the success of image-guided interventions. Here, this work describes the development of renally clearable near-infrared contrast agents and their potential use for dual-channel image-guided tumor targeting. cRGD-ZW800-PEG (800 nm channel) and ZW700-PEG (700 nm channel) are able to visualize tumor margins and tumor vasculature simultaneously and respectively. These targeted agents show rapid elimination from the bloodstream, followed by renal clearance, which together significantly lower off-target background signals and potential toxicity. To demonstrate its applicability, this multispectral imaging is performed in various tumor-bearing animal models including lung cancer, pancreatic neuroendocrine tumors, breast, and ovarian cancer.

引用

页数：8

共 34 条

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