Neutrophils and neutrophil extracellular traps in cancer: promising targets for engineered nanomaterials

被引：11
作者：
Okeke, Emeka B. [1 ,2 ,3 ]
Louttit, Cameron [3 ,4 ]
Snyder, Caitlin M. [1 ]
Moon, James J. [2 ,3 ,4 ,5 ]
机构：
[1] SUNY Coll Fredonia, Dept Biol, Fredonia, NY 14063 USA
[2] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
来源：
DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2023年 / 13卷 / 07期
关键词：
Neutrophil extracellular trap; Neutrophils; Nanoparticle; Cancer; COLONY-STIMULATING FACTOR; DEEP-VEIN THROMBOSIS; POLYMORPHONUCLEAR LEUKOCYTE ELASTASE; CIRCULATING TUMOR-CELLS; SUPPRESSOR-CELLS; NETTING NEUTROPHILS; VENOUS THROMBOSIS; DRUG-DELIVERY; BREAST-CANCER; DNA TRAPS;
D O I：
10.1007/s13346-022-01243-1
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Neutrophils are the most abundant white blood cells in circulation and constitute up to 60% of circulating leukocytes. Neutrophils play a significant role in host defense against pathogens through various mechanisms, including phagocytosis, production of antimicrobial proteins, and formation of neutrophil extracellular traps (NETs). Recently, the role of neutrophils and NETs in cancer has generated significant interest, as accumulating evidence suggests that neutrophils and NETs contribute to cancer progression and are associated with adverse patient outcomes. In this review, we will first highlight the roles of neutrophils and NETs in cancer progression and metastasis and discuss new drug delivery approaches to target and modulate neutrophils and NETs for cancer therapeutics.
引用
收藏
页码：1882 / 1895
页数：14
相关论文
共 116 条
[61]   Neutrophils: Homing in on the myeloid mechanisms of metastasis [J].
Leach, Joshua ;
Morton, Jennifer P. ;
Sansom, Owen J. .
MOLECULAR IMMUNOLOGY, 2019, 110 :69-76
[62]   Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis [J].
Leal, Ana C. ;
Mizurini, Daniella M. ;
Gomes, Taina ;
Rochael, Natalia C. ;
Saraiva, Elvira M. ;
Dias, Marcos S. ;
Werneck, Claudio C. ;
Sielski, Micheli S. ;
Vicente, Cristina P. ;
Monteiro, Robson Q. .
SCIENTIFIC REPORTS, 2017, 7
[63]   Phagocytosis by neutrophils [J].
Lee, WL ;
Harrison, RE ;
Grinstein, S .
MICROBES AND INFECTION, 2003, 5 (14) :1299-1306
[64]   PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps [J].
Li, Pingxin ;
Li, Ming ;
Lindberg, Michael R. ;
Kennett, Mary J. ;
Xiong, Na ;
Wang, Yanming .
JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (09) :1853-1862
[65]  
LIESCHKE GJ, 1994, BLOOD, V84, P1737
[66]   The Interplay Between Nanoparticles and Neutrophils [J].
Lin, Ming-Hsien ;
Lin, Chwan-Fwu ;
Yang, Shih-Chun ;
Hung, Chi-Feng ;
Fang, Jia-You .
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2018, 14 (01) :66-85
[67]   Polymer therapeutics and the EPR effect [J].
Maeda, Hiroshi .
JOURNAL OF DRUG TARGETING, 2017, 25 (9-10) :781-785
[68]   Engineered nanostructural materials for application in cancer biology and medicine [J].
Mahmood, Meena ;
Casciano, Dan ;
Xu, Yang ;
Biris, Alexandru S. .
JOURNAL OF APPLIED TOXICOLOGY, 2012, 32 (01) :10-19
[69]   Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice [J].
Martinod, Kimberly ;
Demers, Melanie ;
Fuchs, Tobias A. ;
Wong, Siu Ling ;
Brill, Alexander ;
Gallant, Maureen ;
Hu, Jing ;
Wang, Yanming ;
Wagner, Denisa D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (21) :8674-8679
[70]   Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients [J].
Mauracher, L. -M. ;
Posch, F. ;
Martinod, K. ;
Grilz, E. ;
Daeullary, T. ;
Hell, L. ;
Brostjan, C. ;
Zielinski, C. ;
Ay, C. ;
Wagner, D. D. ;
Pabinger, I. ;
Thaler, J. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2018, 16 (03) :508-518
234567891011