Neutrophils and neutrophil extracellular traps in cancer: promising targets for engineered nanomaterials

被引：10
作者：
Okeke, Emeka B. [1 ,2 ,3 ]
Louttit, Cameron [3 ,4 ]
Snyder, Caitlin M. [1 ]
Moon, James J. [2 ,3 ,4 ,5 ]
机构：
[1] SUNY Coll Fredonia, Dept Biol, Fredonia, NY 14063 USA
[2] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
来源：
DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2023年 / 13卷 / 07期
关键词：
Neutrophil extracellular trap; Neutrophils; Nanoparticle; Cancer; COLONY-STIMULATING FACTOR; DEEP-VEIN THROMBOSIS; POLYMORPHONUCLEAR LEUKOCYTE ELASTASE; CIRCULATING TUMOR-CELLS; SUPPRESSOR-CELLS; NETTING NEUTROPHILS; VENOUS THROMBOSIS; DRUG-DELIVERY; BREAST-CANCER; DNA TRAPS;
D O I：
10.1007/s13346-022-01243-1
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Neutrophils are the most abundant white blood cells in circulation and constitute up to 60% of circulating leukocytes. Neutrophils play a significant role in host defense against pathogens through various mechanisms, including phagocytosis, production of antimicrobial proteins, and formation of neutrophil extracellular traps (NETs). Recently, the role of neutrophils and NETs in cancer has generated significant interest, as accumulating evidence suggests that neutrophils and NETs contribute to cancer progression and are associated with adverse patient outcomes. In this review, we will first highlight the roles of neutrophils and NETs in cancer progression and metastasis and discuss new drug delivery approaches to target and modulate neutrophils and NETs for cancer therapeutics.
引用
收藏
页码：1882 / 1895
页数：14
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