Neutrophils and neutrophil extracellular traps in cancer: promising targets for engineered nanomaterials

被引：11

作者：

Okeke, Emeka B. ^{[1
,2
,3
]}

Louttit, Cameron ^{[3
,4
]}

Snyder, Caitlin M. ^{[1
]}

Moon, James J. ^{[2
,3
,4
,5
]}

机构：

[1] SUNY Coll Fredonia, Dept Biol, Fredonia, NY 14063 USA

[2] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA

来源：

DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2023年 / 13卷 / 07期

关键词：

Neutrophil extracellular trap; Neutrophils; Nanoparticle; Cancer; COLONY-STIMULATING FACTOR; DEEP-VEIN THROMBOSIS; POLYMORPHONUCLEAR LEUKOCYTE ELASTASE; CIRCULATING TUMOR-CELLS; SUPPRESSOR-CELLS; NETTING NEUTROPHILS; VENOUS THROMBOSIS; DRUG-DELIVERY; BREAST-CANCER; DNA TRAPS;

D O I：

10.1007/s13346-022-01243-1

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Neutrophils are the most abundant white blood cells in circulation and constitute up to 60% of circulating leukocytes. Neutrophils play a significant role in host defense against pathogens through various mechanisms, including phagocytosis, production of antimicrobial proteins, and formation of neutrophil extracellular traps (NETs). Recently, the role of neutrophils and NETs in cancer has generated significant interest, as accumulating evidence suggests that neutrophils and NETs contribute to cancer progression and are associated with adverse patient outcomes. In this review, we will first highlight the roles of neutrophils and NETs in cancer progression and metastasis and discuss new drug delivery approaches to target and modulate neutrophils and NETs for cancer therapeutics.

引用

页码：1882 / 1895

页数：14

共 116 条

[1] Prognostic significance of immunoreactive neutrophil elastase in human breast cancer: Long-term follow-up results in 313 patients [J].

Akizuki, Miwa ;

Fukutomi, Takashi ;

Takasugi, Miyuki ;

Takahashi, Satoshi ;

Sato, Takashi ;

Harao, Michiko ;

Mizumoto, Takao ;

Yamashita, Jun-ichi .

NEOPLASIA, 2007, 9 (03) :260-264

[2] Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice [J].

Albrengues, Jean ;

Shields, Mario A. ;

Ng, David ;

Park, Chun Gwon ;

Ambrico, Alexandra ;

Poindexter, Morgan E. ;

Upadhyay, Priya ;

Uyeminami, Dale L. ;

Pommier, Arnaud ;

Kuttner, Victoria ;

Bruzas, Emilis ;

Maiorino, Laura ;

Bautista, Carmelita ;

Carmona, Ellese M. ;

Gimotty, Phyllis A. ;

Fearon, Douglas T. ;

Chang, Kenneth ;

Lyons, Scott K. ;

Pinkerton, Kent E. ;

Trotman, Lloyd C. ;

Goldberg, Michael S. ;

Yeh, Johannes T. -H. ;

Egeblad, Mikala .

SCIENCE, 2018, 361 (6409) :1353-+

[3] Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs) [J].

Alfaro, Carlos ;

Teijeira, Alvaro ;

Onate, Carmen ;

Perez, Guiomar ;

Sanmamed, Miguel F. ;

Pilar Andueza, Maria ;

Alignani, Diego ;

Labiano, Sara ;

Azpilikueta, Arantza ;

Rodriguez-Paulete, Alfonso ;

Garasa, Saray ;

Fusco, Juan P. ;

Aznar, Angela ;

Inoges, Susana ;

De Pizzol, Maria ;

Allegretti, Marcello ;

Medina-Echeverz, Jose ;

Berraondo, Pedro ;

Perez-Gracia, Jose L. ;

Melero, Ignacio .

CLINICAL CANCER RESEARCH, 2016, 22 (15) :3924-3936

[4] Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury [J].

Bachmaier, Kurt ;

Stuart, Andrew ;

Singh, Abhalaxmi ;

Mukhopadhyay, Amitabha ;

Chakraborty, Sreeparna ;

Hong, Zhigang ;

Wang, Li ;

Tsukasaki, Yoshikazu ;

Maienschein-Cline, Mark ;

Ganesh, Balaji B. ;

Kanteti, Prasad ;

Rehman, Jalees ;

Malik, Asrar B. .

ACS NANO, 2022, 16 (03) :4084-4101

[5] Fluorouracil neutrophil extracellular traps formation inhibited by polymer nanoparticle shielding [J].

Basyreva, Liliya Yu ;

Voinova, Ekaterina V. ;

Gusev, Alexander A. ;

Mikhalchik, Elena V. ;

Kuskov, Andrey N. ;

Goryachaya, Anastasiya V. ;

Gusev, Sergey A. ;

Shtilman, Mikhail I. ;

Velonia, Kelly ;

Tsatsakis, Aristidis M. .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 108

[6] Restoration of NET formation by gene therapy in CGD controls aspergillosis [J].

Bianchi, Matteo ;

Hakkim, Abdul ;

Brinkmann, Volker ;

Siler, Ulrich ;

Seger, Reinhard A. ;

Zychlinsky, Arturo ;

Reichenbach, Janine .

BLOOD, 2009, 114 (13) :2619-2622

[7] Nanomaterial Interactions with Human Neutrophils [J].

Bisso, Paul W. ;

Gaglione, Stephanie ;

Guimaraes, Pedro P. G. ;

Mitchell, Michael J. ;

Langer, Robert .

ACS BIOMATERIALS SCIENCE & ENGINEERING, 2018, 4 (12) :4255-4265

[8] QUANTITATIVE RELATIONSHIPS BETWEEN CIRCULATING LEUKOCYTES AND INFECTION IN PATIENTS WITH ACUTE LEUKEMIA [J].

BODEY, GP ;

BUCKLEY, M ;

SATHE, YS ;

FREIREICH, EJ .

ANNALS OF INTERNAL MEDICINE, 1966, 64 (02) :328-+

[9] The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer [J].

Boone, B. A. ;

Orlichenko, L. ;

Schapiro, N. E. ;

Loughran, P. ;

Gianfrate, G. C. ;

Ellis, J. T. ;

Singhi, A. D. ;

Kang, R. ;

Tang, D. ;

Lotze, M. T. ;

Zeh, H. J. .

CANCER GENE THERAPY, 2015, 22 (06) :326-334

[10] Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps [J].

Boone, Brian A. ;

Murthy, Pranav ;

Miller-Ocuin, Jennifer ;

Doerfler, W. Reed ;

Ellis, Jarrod T. ;

Liang, Xiaoyan ;

Ross, Mark A. ;

Wallace, Callen T. ;

Sperry, Jason L. ;

Lotze, Michael T. ;

Neal, Matthew D. ;

Zeh, Herbert J., III .

BMC CANCER, 2018, 18

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