Long-term efficacy and safety of nonablative monopolar radiofrequency in the treatment of moderate to severe acne vulgaris

被引:2
作者
Manuskiatti, Woraphong [1 ,2 ]
Wongdama, Supisara [1 ]
Viriyaskultorn, Noldtawat [1 ]
Li, Jayne Bernadeth [1 ]
Kulthanan, Kanokvalai [1 ]
Techapichetvanich, Thanya [1 ]
机构
[1] Mahidol Univ, Fac Med, Dept Dermatol, Siriraj Hosp, Bangkok, Thailand
[2] Mahidol Univ, Fac Med, Dept Dermatol, Siriraj Hosp, 2 Wanglang Rd, Bangkok 10700, Thailand
关键词
acne vulgaris; monopolar radiofrequency; quality of life; sebaceous gland; sebum excretion; QUALITY-OF-LIFE; 1726 NM LASER; DERMATOLOGY; OUTCOMES;
D O I
10.1002/lsm.23757
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Acne vulgaris (AV) is a prevalent skin condition known for its potential to cause scarring and psychological distress, often leading to diminished self-esteem. While topical and oral treatments are commonly prescribed, some patients experience treatment failure, adverse effects, or contraindications to conventional therapies. In response to these challenges, laser and energy-based device therapies have emerged as promising alternatives for individuals who fall into these categories, showing considerable potential in the treatment of AV.ObjectiveThis study aimed to evaluate the long-term efficacy and safety of a nonablative monopolar radiofrequency (NMRF) in treatment of moderate to severe AV.Methods: Twenty-four patients with moderate to severe AV underwent a series of two NMRF treatment sessions, spaced 4 weeks apart. To evaluate treatment outcomes, live in-person lesion counts and measurements of pore size and volume, and sebum production were quantified using Antera (R) 3D imaging system, and Sebumeter (R), respectively. Patients' self-assessment data regarding degree of improvement and facial oiliness were gathered. Dermatology life quality index (DLQI) questionnaire was utilized to assess the impact of AV on their quality of life. All objective and subjective evaluations were conducted at the baseline, 1 month after the first treatment, and during follow-up visits 1, 3, and 6 months after the last treatment sessions. Adverse effects were also recorded during each visit.Results: Twenty out of the 24 subjects completed the study protocol. The mean inflammatory lesion counts significantly reduced by 42.86% and 45.71% from the baseline at 3 (p = 0.027) and 6 months (p = 0.032) after the second treatment. Sebum excretion likewise significantly decreased from baseline by 11.62% (p = 0.012), 13.37% (p < 0.001), and 21.51% (p = 0.004), 1 month after the first treatment, 1 and 6 months after the second treatment, respectively. The pore volume continued to decrease by 35% (p = 0.003) and 41.5% (p < 0.001) at 1 and 6 months following the final treatment, respectively. The DLQI significantly decreased from 10.00 (interquartile range [IQR]: 6.50-15.00) to 2.00 (IQR: 1.00-4.75), corresponding to 80% improvement of the index, 1 month after the last treatment and was sustained up to the last follow-up visit. Patients' self-assessments on degree of improvement and facial oiliness also significantly improved following NMRF treatments. The treatments were well-tolerated without significant adverse effects.Conclusion: NMRF appears to be an effective and safe treatment for inflammatory AV, with therapeutic outcomes persisting up to 6 months after two treatment sessions.
引用
收藏
页码:133 / 141
页数:9
相关论文
共 50 条
  • [41] Efficacy of diluted botulinum toxin type A (Microbotox) in treatment of mild to moderate acne vulgaris
    Elshabory, Osama
    Elgamal, Emad Eldin A.
    Abd El Hai, Esraa R.
    Elsaie, Mohamed L.
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2025, 317 (01)
  • [42] Dapsone 5% Gel A Review of its Efficacy and Safety in the Treatment of Acne Vulgaris
    Stotland, Mira
    Shalita, Alan R.
    Kissling, Robert F.
    AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2009, 10 (04) : 221 - 227
  • [43] Efficacy and safety of topical spironolactone versus topical dapsone in the treatment of acne vulgaris
    Gharib, Khaled
    Samir, Mai
    Mohamed, Gehad
    Rageh, Mahmoud A.
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2024, 316 (10)
  • [44] A pilot study of the safety and efficacy of picolinic acid gel in the treatment of acne vulgaris
    Heffernan, M. P.
    Nelson, M. M.
    Anadkat, M. J.
    BRITISH JOURNAL OF DERMATOLOGY, 2007, 156 (03) : 548 - 552
  • [45] Carboxytherapy in management of acne flare in patients with moderate to severe acne vulgaris under treatment with oral isotretinoin: a case series
    Bagherani, Nooshin
    Mirmomeni, Golshan
    Smoller, Bruce R.
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2025, 317 (01)
  • [46] Long-term safety, tolerability and efficacy of fesoterodine treatment in subjects with overactive bladder symptoms
    Van Kerrebroeck, P. E. V.
    Heesakkers, J.
    Berriman, S.
    Aiyer, L. Padmanabhan
    Carlsson, M.
    Guan, Z.
    INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2010, 64 (05) : 584 - 593
  • [47] Dupilumab shows long-term safety and efficacy in patients with moderate to severe atopic dermatitis enrolled in a phase 3 open-label extension study
    Deleuran, Mette
    Thaci, Diamant
    Beck, Lisa A.
    de Bruin-Weller, Marjolein
    Blauvelt, Andrew
    Forman, Seth
    Bissonnette, Robert
    Reich, Kristian
    Soong, Weily
    Hussain, Iftikhar
    Foley, Peter
    Hide, Michihiro
    Bouaziz, Jean-David
    Gelfand, Joel M.
    Sher, Lawrence
    Schuttelaar, Marie L. A.
    Wang, Chen
    Chen, Zhen
    Akinlade, Bolanle
    Gadkari, Abhijit
    Eckert, Laurent
    Davis, John D.
    Rajadhyaksha, Manoj
    Staudinger, Heribert
    Graham, Neil M. H.
    Pirozzi, Gianluca
    Ardeleanu, Marius
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2020, 82 (02) : 377 - 388
  • [48] Long-term incobotulinumtoxinA treatment for chronic sialorrhea: Efficacy and safety over 64 weeks
    Jost, Wolfgang H.
    Friedman, Andrzej
    Michel, Olaf
    Oehlwein, Christian
    Slawek, Jaroslaw
    Bogucki, Andrzej
    Ochudlo, Stanislaw
    Banach, Marta
    Pagan, Fernando
    Flatau-Baque, Birgit
    Dorsch, Ulrike
    Csikos, Janos
    Blitzer, Andrew
    PARKINSONISM & RELATED DISORDERS, 2020, 70 : 23 - 30
  • [49] Long-term efficacy and safety of polyalkylimide gel for the treatment of HIV-associated lipoatrophy
    Antoniou, Tony
    Raboud, Janet M.
    Kovacs, Colin
    Diong, Christina
    Brunetta, Jason
    Smith, Graham
    Halpenny, Roberta
    Beninger, Francis
    Loutfy, Mona R.
    AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2009, 21 (10): : 1247 - 1252
  • [50] Long-term safety and efficacy of autologous platelet lysate drops for treatment of ocular GvHD
    Pezzotta, S.
    Del Fante, C.
    Scudeller, L.
    Rossi, G. C.
    Perotti, C.
    Bianchi, P. E.
    Antoniazzi, E.
    BONE MARROW TRANSPLANTATION, 2017, 52 (01) : 101 - 106