Evaluating the association between longitudinal exposure to a PFAS mixture and adolescent cardiometabolic risk in the HOME Study

被引:1
作者
Fleury, Elvira S. [1 ]
Kuiper, Jordan R. [2 ]
Buckley, Jessie P. [3 ]
Papandonatos, George D. [4 ]
Cecil, Kim M. [5 ]
Chen, Aimin [6 ]
Eaton, Charles B. [7 ]
Kalkwarf, Heidi J. [8 ]
Lanphear, Bruce P. [9 ]
Yolton, Kimberly [8 ]
Braun, Joseph M. [1 ]
机构
[1] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA
[2] George Washington Univ, Milken Inst Sch Publ Hlth, Dept Environm & Occupat Hlth, Washington, DC USA
[3] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA
[4] Brown Univ, Dept Biostat, Providence, RI USA
[5] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Dept Radiol, Cincinnati, OH USA
[6] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA USA
[7] Brown Univ, Warren Alpert Med Sch, Dept Family Med, Providence, RI USA
[8] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA
[9] Simon Fraser Univ, Fac Hlth Sci, Vancouver, BC, Canada
关键词
Adolescents; Cardiometabolic risk; Chemical mixture; Latent profile analysis; polyfluoroalkyl substances; PERFLUOROALKYL SUBSTANCES; PERFLUORINATED COMPOUNDS; SERUM CONCENTRATIONS; POLYFLUOROALKYL SUBSTANCES; CHILDREN; AGE; PERFLUOROOCTANOATE; PREDICTORS; CHILDHOOD; PREGNANCY;
D O I
10.1097/EE9.0000000000000289
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background:Exposure to per- and polyfluoroalkyl substances (PFAS) throughout gestation and childhood may impact cardiometabolic risk.Methods:In 179 HOME Study participants (Cincinnati, OH; recruited 2003-2006), we used latent profile analysis to identify two distinct patterns of PFAS exposure from serum concentrations of four PFAS measured at birth and ages 3, 8, and 12 years. We assessed the homeostatic model of insulin resistance, triglycerides-to-high-density lipoprotein cholesterol ratio, leptin-to-adiponectin ratio, systolic blood pressure, visceral fat, and hemoglobin A1c levels at age 12 years. We used multivariable linear regression to assess the association of membership in the longitudinal PFAS mixture exposure group with a summary measure of overall cardiometabolic risk and individual components.Results:One PFAS exposure profile (n = 66, 39%) had higher geometric means of all PFAS across all visits than the other. Although adjusted associations were null in the full sample, child sex modified the association of longitudinal PFAS mixture exposure group with overall cardiometabolic risk, leptin-to-adiponectin ratio, systolic blood pressure, and visceral fat (interaction term P values: 0.02-0.08). Females in the higher exposure group had higher cardiometabolic risk scores (ss = 0.43; 95% CI = -0.08, 0.94), systolic blood pressures (ss = 0.6; 95% CI = 0.1, 1.1), and visceral fat (ss = 0.44; 95% CI = -0.13, 1.01); males had lower cardiometabolic risk scores (ss = -0.52; 95% CI = -1.06, -0.06), leptin-to-adiponectin ratios (ss = -0.7; 95% CI = -1.29, -0.1), systolic blood pressures (ss = -0.14; 95% CI = -0.7, 0.41), and visceral fat (ss = -0.52; 95% CI = -0.84, -0.19).Conclusions:Exposure to this PFAS mixture throughout childhood may have sex-specific effects on adolescent cardiometabolic risk.
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页数:8
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