Diet as an epigenetic factor in inflammatory bowel disease

被引：5

作者：

Marangoni, Karina ^{[1
,2
]}

Dorneles, Gilson ^{[3
]}

da Silva, Daniella Miranda ^{[4
,5
]}

Pinto, Leticia Pereira ^{[6
]}

Rossoni, Carina ^{[7
,8
,9
]}

Fernandes, Sabrina Alves ^{[6
,10
]}

机构：

[1] Egas Moniz Sch Hlth & Sci, P-2820062 Caparica, Portugal

[2] Univ Fed Uberlandia, Natl Inst Sci & Technol Theranost & Nanobiotechnol, BR-38400902 Uberlandia, MG, Brazil

[3] Hosp Moinhos De Vento, Corp Social Responsibil, BR-90035004 Porto Alegre, Brazil

[4] Univ Fed Rio Grande Do Sul, Postgrad Program Gastroenterol, BR-91540000 Porto Alegre, Brazil

[5] Uniasselvi Grp Vitru, Dept Nutr, BR-89082262 Florianopolis, SC, Brazil

[6] Univ Fed Ciencias Saude Porto Alegre, Postgrad Program Hepatol, BR-90050170 Porto Alegre, Brazil

[7] Univ Lisbon, Inst Environm Hlth, Fac Med, P-1649026 Lisbon, Portugal

[8] Polytech Inst Beja, Phys Act & Hlth, P-7800000 Beja, Portugal

[9] Lusofona Univ, Nutr Sci, P-1749024 Lisbon, Portugal

[10] Univ Fed Ciencias Saude Porto Alegre, Postgrad Program Hepatol, Sarmento Leite 245, BR-90050170 Porto Alegre, Brazil

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2023年 / 29卷 / 41期

关键词：

Inflammatory bowel disease; Epigenetics; Nutrition; Nutrigenetics; ONE-CARBON METABOLISM; VITAMIN-D DEFICIENCY; PATHOGENESIS; MICRORNAS; THERAPY; TARGETS; ACID;

D O I：

10.3748/wjg.v29.i41.5618

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD) has as a main characteristic the exacerbation of the immune system against enterocytes, compromising the individual's intestinal microbiota. This inflammatory cascade causes several nutritional deficiencies, which further compromise immunological functioning and, as a result, worsen the prognosis. This vicious cycle can be interrupted as the patient's dietary pattern meets their needs according to their clinical condition, acting directly on the inflammatory process of IBD through the interaction of food, intestinal microbiota, and epigenome. Specific nutritional intervention for IBD has a crucial role in preventing and managing disease activity. This review addresses epigenetic modifications through dietary compounds as a mechanism for modulating the intestinal microbiota of patients with IBD.

引用

页码：5618 / 5629

页数：12

共 50 条

[1] Diet in Inflammatory Bowel Disease
Issa, Mazen
Saeian, Kia
NUTRITION IN CLINICAL PRACTICE, 2011, 26 (02) : 151 - 154
[2] Epigenetic Alterations in Inflammatory Bowel Disease and Cancer
Yi, Joo Mi
Kim, Tae Oh
INTESTINAL RESEARCH, 2015, 13 (02) : 112 - 121
[3] Diet and Risk of Inflammatory Bowel Disease
不详
GASTROENTEROLOGY, 2020, 159 (03) : 803 - 804
[4] Role of Diet in Inflammatory Bowel Disease
Ruemmele, Frank M.
ANNALS OF NUTRITION AND METABOLISM, 2016, 68 : 33 - 41
[5] Genes, diet and inflammatory bowel disease
Ferguson, Lynnette R.
Shelling, Andrew N.
Browning, Brian L.
Huebner, Claudia
Petermann, Ivonne
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2007, 622 (1-2) : 70 - 83
[6] Diet in the etiology of inflammatory bowel disease
Hart, Andrew
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, 2019, 111 (01) : 3 - 4
[7] The Role of Diet in Inflammatory Bowel Disease
Shivashankar R.
Lewis J.D.
Current Gastroenterology Reports, 2017, 19 (5)
[8] Nutrition and diet in inflammatory bowel disease
Yamamoto, Takayuki
Shimoyama, Takahiro
CURRENT OPINION IN GASTROENTEROLOGY, 2023, 39 (02) : 110 - 114
[9] Diet and risk of inflammatory bowel disease
Andersen, Vibeke
Olsen, Anja
Carbonnel, Franck
Tjonneland, Anne
Vogel, Ulla
DIGESTIVE AND LIVER DISEASE, 2012, 44 (03) : 185 - 194
[10] Nutrition and diet in inflammatory bowel disease
Yamamoto, Takayuki
CURRENT OPINION IN GASTROENTEROLOGY, 2013, 29 (02) : 216 - 221

← 1 2 3 4 5 →