Prediction of lymph node metastasis in early esophageal cancer

被引:2
作者
Li, Yan [1 ]
Wang, Jun-Xiong [2 ,3 ]
Yibi, Ran-Hen [1 ]
机构
[1] Lhasa Peoples Hosp, Dept Gastroenterol, 1 Beijing Zhong Rd, Lhasa 850000, Tibet Autonomou, Peoples R China
[2] Capital Med Univ, Beijing Friendship Hosp, Dept Gastroenterol, Beijing 100000, Peoples R China
[3] Beijing Digest Dis Ctr, Natl Clin Res Ctr Digest Dis, Beijing Key Lab Precancerous Les Digest Dis, Beijing 100000, Peoples R China
来源
WORLD JOURNAL OF GASTROINTESTINAL SURGERY | 2023年 / 15卷 / 10期
关键词
Early esophageal cancer; Esophageal squamous cell carcinoma; Esophageal adenocarcinoma; Lymph node metastasis; Systematic review; SQUAMOUS-CELL CARCINOMA; CLINICAL CHARACTERISTICS; PROGNOSTIC IMPACT; ADENOCARCINOMA; PIM-1; OVEREXPRESSION; EXPRESSION; DIAGNOSIS; CORRELATE; RESECTION;
D O I
10.4240/wjgs.v15.i10.2294
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BACKGROUND Given the poor prognosis of patients with lymph node metastasis, estimating the lymph node status in patients with early esophageal cancer is crucial. Indicators that could be used to predict lymph node metastasis in early esophageal cancer have been reported in many recent studies, but no recent studies have included a review of this subject.AIM To review indicators predicting lymph node metastasis in early esophageal squamous cell carcinoma (ESCC) and early esophageal adenocarcinoma (EAC).METHODS We searched PubMed with "[early esophageal cancer (Title/Abstract)] and [lymph node (Title/Abstract)]" or "[early esophageal carcinoma (Title/Abstract)] and [lymph node (Title/Abstract)]" or "[superficial esophageal cancer (Title/Abstract)] and [lymph node (Title/Abstract)]." A total of 29 studies were eligible for analysis.RESULTS Preoperative imaging (size), serum markers (microRNA-218), postoperative pathology and immunohistochemical analysis (depth of invasion, tumor size, differentiation grade, lymphovascular invasion, neural invasion, expression of PIM-1 < 30%) were predictive factors for lymph node metastasis in both early ESCC and EAC. Serum markers (thymidine kinase 1 >= 3.38 pmol/L; cytokeratin 19 fragment antigen 21-1 > 3.30 ng/mL; stathmin-1) and postoperative pathology and immunohistochemical analysis (overexpression of cortactin, mixed-lineage leukaemia 2, and stanniocalcin-1) were predictive for lymph node metastasis in early ESCC. Transcription of CD69, myeloid differentiation protein 88 and toll-like receptor 4 and low expression of olfactomedin 4 were predictive of lymph node metastasis in early EAC. A total of 6 comprehensive models for early ESCC, including logistic regression model, nomogram, and artificial neural network (ANN), were reviewed. The areas under the receiver operating characteristic curve of these models reached 0.789-0.938, and the ANN performed best. As all these models relied on postoperative pathology, further models focusing on serum markers, imaging and immunohistochemical indicators are still needed.CONCLUSION Various factors were predictive of lymph node metastasis in early esophageal cancer, and present comprehensive models predicting lymph node metastasis in early ESCC mainly relied on postoperative pathology. Further studies focusing on serum markers, imaging and immunohistochemical indicators are still in need.
引用
收藏
页码:2294 / 2304
页数:11
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