Valproic acid-induced tremor and cognitive slowing

被引：0

作者：

Lamprecht, Ann-Kristin ^{[1
,4
]}

Miosge, Ragna-Jill ^{[1
,2
]}

Kruemmer, Norma ^{[1
,3
]}

Berrouschot, Joerg ^{[1
]}

Kleine, Bert-Ulrich ^{[1
,3
]}

机构：

[1] Univ Jenaund Leipzig, Klin Neurol & Neurol Intensivmed, Klinikum Altenburger Land, Akad Lehrkrankenhaus, Altenburg, Germany

[2] MVZ Schmolln, Med Versorgungszentren Altenburger Land, Schmolln, Germany

[3] MVZ Altenburg, Med Versorgungszentren Altenburger Land, Altenburg, Germany

[4] Klinikum Altenburger Land, Klin Neurol & Neurol Intensivmed, Waldessaum 10, D-04600 Altenburg, Germany

来源：

CLINICAL EPILEPTOLOGY | 2024年 / 37卷 / 01期

关键词：

Case report; Focal epilepsy; Valproic acid-induced encephalopathy; Valproic acid-associated parkinsonism; Valproate;

D O I：

10.1007/s10309-023-00638-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report on a 79-year-old female patient with focal epilepsy and cognitive status epilepticus suffering from progressive cognitive slowing and extrapyramidal symptoms during treatment with valproic acid (VPA). A switch from VPA to lacosamide led to impressive but gradual clinical improvement over months. We show that a complete remission of symptoms following discontinuation of VPA can be expected and discuss pitfalls of an early diagnosis and treatment in cases with comorbidities.

引用

页码：36 / 40

页数：5

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