(Betaine: Citric Acid: H2O) a Natural Deep Eutectic Solvent (NaDES)-Mediated Efficient and Green Synthesis of 4-Benzylidene Isoxazol-5-one Derivatives

被引：3
|
作者：
Zadem, Achwaq [1 ]
Cheraiet, Zinelaabidine [1 ,2 ]
Chahra, Bidjou-Haiour [1 ]
机构：
[1] Badji Mokhtar Annaba Univ, Fac Sci, Dept Chem, Organ Synth Lab Modeling & Optimizat Chem Proc LOM, Annaba, Algeria
[2] Univ Echahid Larbi Tebessi, Dept Sci Matiere, Lab Mat Organ & Heterochim LMOH, Tebessa, Tebessa, Algeria
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2024年 / 44卷 / 08期
关键词：
Natural deep eutectic solvent; betaine; isoxazolones; eco-compatible; multi-components reaction; microwave; ONE-POT SYNTHESIS; 3-COMPONENT SYNTHESIS; CHOLINE CHLORIDE; AQUEOUS-MEDIA; 3-METHYL-4-ARYLMETHYLENE-ISOXAZOL-5(4H)-ONES; MIXTURES;
D O I：
10.1080/10406638.2023.2261594
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A biodegradable catalyst based on natural deep eutectic solvents (NaDESs) designed from Betaine and natural acids (Betaine: Citric Acid: H2O) with a molar ratio of (1:1.5:1) has been utilized in one-pot multi-component reaction for the synthesis of Isoxazol-5-ones derivatives in a mild, green and efficient manner. The reaction was carried out under different conditions that are, at 40 degrees C, ultrasonic and microwave. The developed method provided many advantages, including an excellent yield of up to 98% in a shorter reaction time, avoiding the use of toxic solvents and an easy handling process. Additionally, the use of NaDESs enabled the conservation of resources due to their simple preparation. The developed process adheres to the requirements of green chemistry by employing a bio-sourced and recyclable catalyst. [GRAPHICS] .
引用
收藏
页码：5188 / 5200
页数：13
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