Host-Guest Interaction-Based Supramolecular Self-Assemblies for H2O2 Upregulation Augmented Chemiluminescence Resonance Energy Transfer-Induced Cancer Therapy

被引：5

作者：

Liu, Caiping ^{[1
]}

Bu, Huaitian ^{[1
]}

Duan, Xiao ^{[2
]}

Li, Hui ^{[3
]}

Bai, Yang ^{[1
]}

机构：

[1] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Peoples R China

[2] Changzhi Med Univ, Dept Pharm, Changzhi 046000, Peoples R China

[3] Jiangxi Univ Sci & Technol, Sch Met & Chem Engn, Ganzhou 341000, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2023年 / 15卷 / 32期

基金：

中国国家自然科学基金;

关键词：

beta-cyclodextrin; host-guest interactions; supramolecular polymer self-assemblies; chemiluminescence resonance energy transfer; photodynamic therapy; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS;

D O I：

10.1021/acsami.3c06353

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Given that light is hard to reach deep tumor tissue, how to enhance photodynamic therapy (PDT) efficacy is a big challenge. Herein, we proposed the supramolecular polymer self-assemblies (HACP) with bis[2,4,5-trichloro-6 (penty-loxycar-bonyl) phenyl] oxalate as the cargos (HACP@CPPO) to realize the chemiluminescence resonance energy transfer (CRET)-induced generation of O-1(2) in situ. HACP was prepared by cinnamaldehyde-modified hyaluronic acid (HA-CA) and beta-cyclodextrin-modified protoporphyrin IX (beta-CD-PPIX) via host-guest interactions. The CA moiety could elevate H2O2 levels for the enhanced production of chemical energy and macrocyclic CD could enhance the stacking distance of PPIX for enhanced O-1(2) yield. Thus, HACP@CPPO exhibited excellent antitumor performance without light irradiation.

引用

页码：38264 / 38272

页数：9

共 7 条

[1] Host-Guest Interaction-Based Supramolecular Self-Assemblies for H2O2 Upregulation Augmented Chemiluminescence Resonance Energy Transfer-Induced Cancer Therapy (vol 15, pg 38264, 2023)
Liu, Caiping
Bu, Huaitian
Duan, Xiao
Li, Hui
Bai, Yang
ACS APPLIED MATERIALS & INTERFACES, 2023, 15 (43) : 50546 - 50546
[2] Host-guest interaction-based supramolecular prodrug self-assemblies for GSH-consumption augmented chemotherapy
Bai, Yang
Li, Xihua
Li, Muqiong
Shang, Qingqing
Yang, Jing
Fan, Li
Tian, Wei
JOURNAL OF MATERIALS CHEMISTRY B, 2022, 10 (26) : 4952 - 4958
[3] Host-guest interactions based supramolecular complexes self-assemblies for amplified chemodynamic therapy with H2O2 elevation and GSH consumption properties
Bai, Yang
Pan, Yujie
An, Na
Zhang, Haitao
Wang, Chao
Tian, Wei
Huang, Tao
CHINESE CHEMICAL LETTERS, 2023, 34 (01)
[4] Host-guest interactions based supramolecular complexes self-assemblies for amplified chemodynamic therapy with H2O2 elevation and GSH consumption properties
Yang Bai
Yujie Pan
Na An
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Chao Wang
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Tao Huang
ChineseChemicalLetters, 2023, 34 (01) : 397 - 402
[5] Supramolecular Self-Assemblies with Self-Supplying H2O2 and Self- Consuming GSH Property for Amplified Chemodynamic Therapy
Bai, Yang
Shang, Qingqing
Wu, Jing
Zhang, Haitao
Liu, Caiping
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ACS APPLIED MATERIALS & INTERFACES, 2022, 14 (33) : 37424 - 37435
[6] A self-powered photoelectrochemical biosensor for H2O2, and xanthine oxidase activity based on enhanced chemiluminescence resonance energy transfer through slow light effect in inverse opal TiO2
Cakiroglu, Bekir
Ozacar, Mahmut
BIOSENSORS & BIOELECTRONICS, 2019, 141
[7] Fluorescence Detection of 4-Hydroxy-2,5-dimethyl-3(2H)-furanone Based on Fluorescence Resonance Energy Transfer and Competitive Host-Guest Recognition
Zhang, Xiaowan
Wang, Chenchen
Zhuang, Yurong
Wang, Dingzhong
Li, Peng
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Wei, Wei
CHEMOSENSORS, 2025, 13 (03)

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