Roles of extracellular adenosine triphosphate on the functions of periodontal ligament cells

被引：6

作者：

Kyawsoewin, Maythwe ^{[1
,2
,3
]}

Manokawinchoke, Jeeranan ^{[1
,2
,3
]}

Namangkalakul, Worachat ^{[1
,2
,3
]}

Egusa, Hiroshi ^{[4
,5
]}

Limraksasin, Phoonsuk ^{[1
,2
,3
,4
]}

Osathanon, Thanaphum ^{[1
,2
,3
]}

机构：

[1] Chulalongkorn Univ, Fac Dent, Dent Stem Cell Biol Res Unit, Bangkok, Thailand

[2] Chulalongkorn Univ, Fac Dent, Dept Anat, Bangkok, Thailand

[3] Chulalongkorn Univ, Ctr Excellence Regenerat Dent, Bangkok, Thailand

[4] Tohoku Univ, Div Mol & Regenerat Prosthodont, Grad Sch Dent, Sendai, Miyagi, Japan

[5] Tohoku Univ, Ctr Adv Stem Cell & Regenerat Res, Grad Sch Dent, Sendai, Miyagi, Japan

来源：

BDJ OPEN | 2023年 / 9卷 / 01期

关键词：

P2 PURINERGIC RECEPTORS; MECHANICAL-STRESS; STEM-CELLS; ATP RELEASE; T-CELLS; EXPRESSION; PROLIFERATION; DIFFERENTIATION; REGENERATION; ACTIVATION;

D O I：

10.1038/s41405-023-00147-7

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

ObjectiveAdenosine triphosphate (ATP) is an essential nucleotide that is normally present in both intracellular and extracellular compartments. Extracellular ATP (eATP) has a pivotal role in both physiological and pathological processes of periodontal ligament tissues. Here, this review aimed to explore the various functions of eATP that are involved in the control of behaviours and functions of periodontal ligament cells.MethodsTo identify the included publications for review, the articles were searched in PubMed (MEDLINE) and SCOPUS with the keywords of adenosine triphosphate and periodontal ligament cells. Thirteen publications were used as the main publications for discussion in the present review.ResultseATP has been implicated as a potent stimulator for inflammation initiation in periodontal tissues. It also plays a role in proliferation, differentiation, remodelling, and immunosuppressive functions of periodontal ligament cells. Yet, eATP has diverse functions in regulating periodontal tissue homeostasis and regeneration.ConclusioneATP may provide a new prospect for periodontal tissue healing as well as treatment of periodontal disease especially periodontitis. It may be utilized as a useful therapeutic tool for future periodontal regeneration therapy.

引用

页数：10

共 72 条

[31] Extracellular adenosine triphosphate induces IDO and IFNγ expression of human periodontal ligament cells through P2X7 receptor signaling [J].