Engineered exosomes for cancer theranostics: Next-generation tumor targeting

被引：11
|
作者：
Chavda, Vivek P. [1 ,12 ]
Sugandhi, Vrashabh V. [2 ]
Pardeshi, Chandrakantsing V. [3 ]
Patil, Rahul Jaywant [4 ]
Joshi, Mit [5 ]
Patel, Bhoomika [5 ,11 ]
Khadela, Avinash [6 ]
Bezbaruah, Rajashri [7 ]
Bhattacharjee, Bedanta [8 ]
Balar, Pankti C. [9 ]
Vora, Lalitkumar K. [10 ]
机构：
[1] LM Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, Ahmadabad 380009, India
[2] Y B Chavan Coll Pharm, Dept Pharmaceut, Aurangabad 431001, Maharashtra, India
[3] R C Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Shirpur 425405, Maharashtra, India
[4] Shree Dhanvantary Pharm Coll, Dept Pharmaceut, Kim 394110, Gujarat, India
[5] Nirma Univ, Inst Pharm, Dept Pharmacol, Ahmadabad, India
[6] LM Coll Pharm, Dept Pharmacol, Ahmadabad 380009, India
[7] Dibrugarh Univ, Fac Sci & Engn, Dept Pharmaceut Sci, Dibrugarh 786004, Assam, India
[8] Girijananda Chowdhury Inst Pharmaceut Sci, Tezpur 784501, Assam, India
[9] LM Coll Pharm, Pharm Sect, Ahmadabad 380009, India
[10] Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, North Ireland
[11] Natl Forens Sci Univ, Gandhinagar 382007, Gujarat, India
[12] L M Coll Pharm, Dept Pharmaceut, Ahmadabad 380009, Gujarat, India
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 85卷
关键词：
Extracellular vesicles; Exosome; Cancer; Theranostic; Engineered exosome; MESENCHYMAL STEM-CELLS; MILK-DERIVED EXOSOMES; HUMAN BONE-MARROW; DRUG-DELIVERY; EXTRACELLULAR VESICLES; SURFACE MODIFICATION; NANOPARTICLES; BIOMARKER; BLOOD; EXPRESSION;
D O I：
10.1016/j.jddst.2023.104579
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Exosomes are multivesicular bodies of which the plasma membrane fuse to release the caring moiety into the surrounding body fluids. They are well knwon for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell to another. These "naturally equipped" nanovesicles could be therapeutically targeted or engineered as drug delivery systems. The use of exosomes in cancer detection and prognosis has attracted a great deal of interest from academics. In addition to chemical, biological, and genetic engineering approaches, other current exosomal alteration methodologies hold promise for the advancement of therapeutic medicines for cancer. In this review, we highlight the theranostic potential of exosomes for therapeutic delivery in various cancers.
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页数：17
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