Engineered exosomes for cancer theranostics: Next-generation tumor targeting

被引：11

作者：

Chavda, Vivek P. ^{[1
,12
]}

Sugandhi, Vrashabh V. ^{[2
]}

Pardeshi, Chandrakantsing V. ^{[3
]}

Patil, Rahul Jaywant ^{[4
]}

Joshi, Mit ^{[5
]}

Patel, Bhoomika ^{[5
,11
]}

Khadela, Avinash ^{[6
]}

Bezbaruah, Rajashri ^{[7
]}

Bhattacharjee, Bedanta ^{[8
]}

Balar, Pankti C. ^{[9
]}

Vora, Lalitkumar K. ^{[10
]}

机构：

[1] LM Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, Ahmadabad 380009, India

[2] Y B Chavan Coll Pharm, Dept Pharmaceut, Aurangabad 431001, Maharashtra, India

[3] R C Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Shirpur 425405, Maharashtra, India

[4] Shree Dhanvantary Pharm Coll, Dept Pharmaceut, Kim 394110, Gujarat, India

[5] Nirma Univ, Inst Pharm, Dept Pharmacol, Ahmadabad, India

[6] LM Coll Pharm, Dept Pharmacol, Ahmadabad 380009, India

[7] Dibrugarh Univ, Fac Sci & Engn, Dept Pharmaceut Sci, Dibrugarh 786004, Assam, India

[8] Girijananda Chowdhury Inst Pharmaceut Sci, Tezpur 784501, Assam, India

[9] LM Coll Pharm, Pharm Sect, Ahmadabad 380009, India

[10] Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, North Ireland

[11] Natl Forens Sci Univ, Gandhinagar 382007, Gujarat, India

[12] L M Coll Pharm, Dept Pharmaceut, Ahmadabad 380009, Gujarat, India

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 85卷

关键词：

Extracellular vesicles; Exosome; Cancer; Theranostic; Engineered exosome; MESENCHYMAL STEM-CELLS; MILK-DERIVED EXOSOMES; HUMAN BONE-MARROW; DRUG-DELIVERY; EXTRACELLULAR VESICLES; SURFACE MODIFICATION; NANOPARTICLES; BIOMARKER; BLOOD; EXPRESSION;

D O I：

10.1016/j.jddst.2023.104579

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Exosomes are multivesicular bodies of which the plasma membrane fuse to release the caring moiety into the surrounding body fluids. They are well knwon for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell to another. These "naturally equipped" nanovesicles could be therapeutically targeted or engineered as drug delivery systems. The use of exosomes in cancer detection and prognosis has attracted a great deal of interest from academics. In addition to chemical, biological, and genetic engineering approaches, other current exosomal alteration methodologies hold promise for the advancement of therapeutic medicines for cancer. In this review, we highlight the theranostic potential of exosomes for therapeutic delivery in various cancers.

引用

页数：17

共 50 条

[21] Next-generation Theranostics: Functionalized Nanomaterials Enable Efficient Diagnosis and Therapy of Tuberculosis
Li, Bin
Tan, Qingqin
Fan, Zhijin
Xiao, Keng
Liao, Yuhui
ADVANCED THERAPEUTICS, 2020, 3 (09)
[22] Extracellular vesicles, the cornerstone of next-generation cancer diagnosis?
Weng, Jiayi
Xiang, Xiaoqiang
Ding, Lingwen
Wong, Andrea Li-Ann
Zeng, Qi
Sethi, Gautam
Wang, Lingzhi
Lee, Soo Chin
Goh, Boon Cher
SEMINARS IN CANCER BIOLOGY, 2021, 74 : 105 - 120
[23] Nanoparticles Targeting and Remodeling Tumor Microenvironment for Cancer Theranostics
Lin, Gan
Chen, Shaoyi
Mi, Peng
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2018, 14 (07) : 1189 - 1207
[24] A Comment on Pluripotent Stem Cells in Next-Generation Biomedical Theranostics
Rossbach, M.
CURRENT MOLECULAR MEDICINE, 2013, 13 (05) : 879 - 883
[25] Engineered Exosomes as Theranostic Platforms for Cancer Treatment
Yang, Xu
Xie, Xiangyu
Liu, Songbin
Ma, Wei
Zheng, Zhi
Wei, Hua
Yu, Cui-Yun
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2023, 9 (10) : 5479 - 5503
[26] Exosomes as an Exciting Class of a Next-Generation Therapeutic Platform and their Role in Diagnostics
Bobade, Sumedha
Vijayarani, K.
Timurugaan, K. G.
Thangavelu, A.
Vairamuthu, S.
Kalaiseivi, G.
BIOSCIENCE BIOTECHNOLOGY RESEARCH COMMUNICATIONS, 2019, 12 (04): : 1123 - 1133
[27] Engineered Exosomes for Tumor-Targeted Drug Delivery: A Focus on Genetic and Chemical Functionalization
Akbari, Ali
Nazari-Khanamiri, Fereshteh
Ahmadi, Mahdi
Shoaran, Maryam
Rezaie, Jafar
PHARMACEUTICS, 2023, 15 (01)
[28] Efficient encapsulation of biocompatible nanoparticles in exosomes for cancer theranostics
Tanziela, Tanziela
Shaikh, Sana
Jiang, Hui
Lu, Zuhong
Wang, Xuemei
NANO TODAY, 2020, 35 (35)
[29] Next-generation engineered nanogold for multimodal cancer therapy and imaging: a clinical perspectives
Madhusudhan Alle
Garima Sharma
Seung-Hwan Lee
Jin-Chul Kim
Journal of Nanobiotechnology, 20
[30] Advances in engineered exosomes towards cancer diagnosis and therapeutics
Tanziela, Tanziela
Dong, Xiawei
Ye, Jing
Guo, Zengchao
Jiang, Hui
Lu, Zuhong
Liu, Xiaohui
Wang, Xuemei
PROGRESS IN BIOMEDICAL ENGINEERING, 2022, 4 (03):

← 1 2 3 4 5 →