β Cell and Autophagy: What Do We Know?

被引：16

作者：

Mohammadi-Motlagh, Hamid-Reza ^{[1
]}

Sadeghalvad, Mona ^{[2
]}

Yavari, Niloofar ^{[3
]}

Primavera, Rosita ^{[4
]}

Soltani, Setareh ^{[5
]}

Chetty, Shashank ^{[4
]}

Ganguly, Abantika ^{[4
]}

Regmi, Shobha ^{[4
]}

Floyel, Tina ^{[6
]}

Kaur, Simranjeet ^{[6
]}

Mirza, Aashiq H. H. ^{[6
,7
]}

Thakor, Avnesh S. S. ^{[4
]}

Pociot, Flemming ^{[6
,8
]}

Yarani, Reza ^{[4
,6
]}

机构：

[1] Kermanshah Univ Med Sci, Hlth Technol Inst, Med Biol Res Ctr, Kermanshah 671551616, Iran

[2] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran 1416634793, Iran

[3] Univ Copenhagen, Panum Inst, Fac Hlth & Med Sci, Dept Cellular & Mol Med, DK-2200 Copenhagen, Denmark

[4] Stanford Univ, Sch Med, Dept Radiol, Intervent Regenerat Innovat Stanford IRIS, Palo Alto, CA 94304 USA

[5] Kermanshah Univ Med Sci, Taleghani & Imam Ali Hosp, Clin Res Dev Ctr, Kermanshah 671451673, Iran

[6] Steno Diabet Ctr Copenhagen, Dept Clin Res, Translat Type Diabet Res 1, DK-2730 Herlev, Denmark

[7] Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA

[8] Univ Copenhagen, Inst Clin Med, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark

来源：

BIOMOLECULES | 2023年 / 13卷 / 04期

关键词：

beta cell; autophagy; insulin homeostasis; autophagy modulators; type; 1; diabetes; 2; ENDOPLASMIC-RETICULUM STRESS; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; RAPAMYCIN INDUCES AUTOPHAGY; GENOME-WIDE ASSOCIATION; FATTY-ACIDS; INSULIN-SECRETION; OXIDATIVE STRESS; ER STRESS; MITOCHONDRIAL AUTOPHAGY; MTOR INHIBITION;

D O I：

10.3390/biom13040649

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic beta cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in beta cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in beta cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects beta cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect beta cells' fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to cell failure.

引用

页数：25

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