Practicable diagnostics of Sjogren's syndrome in interstitial lung disease-A discussion article

被引：0

作者：

Aringer, Martin ^{[1
,2
]}

Koschel, Dirk ^{[2
,3
,8
]}

Doerner, Thomas ^{[4
]}

Sewerin, Philipp ^{[5
,9
]}

Prasse, Antje ^{[6
]}

Witte, Torsten ^{[7
]}

机构：

[1] Tech Univ Dresden, Univ Klinikum & Med, Med Klin & Poliklin 3, Fak Carl Gustav Carus,Bereich Rheumatol, Dresden, Germany

[2] Tech Univ Dresden, Univ Klinikum & Med, Univ Centrum Autoimmun & Rheumat Erkrankungen UCA, Fak Carl Gustav Carus, Dresden, Germany

[3] Tech Univ Dresden, Univ Klinikum & Med, Univ Centrum Autoimmun & Rheumat Erkrankungen UCA, Bereich Pneumol,Med Klin & Poliklin 1, Dresden, Germany

[4] Charite Univ Med Berlin, Med Klin Schwerpunkt Rheumatol & Klin Immunol, Berlin, Germany

[5] Rheumazentrum Ruhrgebiet, Herne, Germany

[6] Hannover Med Sch, Klin Pneumol, Hannover, Germany

[7] Hannover Med Sch, Klin Rheumatol & Immunol, Hannover, Germany

[8] Fachkrankenhaus Coswig, Abt Innere Med Pneumol, Coswig, Germany

[9] Ruhr Univ Bochum, Bochum, Germany

来源：

ZEITSCHRIFT FUR RHEUMATOLOGIE | 2023年 / 82卷 / 04期

关键词：

Sjogren's syndrome; Interstitial lung disease; Sicca symptoms; Antinuclear antibodies; Salivary gland sonography; ALPHA-FODRIN; ANTIBODIES;

D O I：

10.1007/s00393-023-01344-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sjogren's syndrome (SjS) is a possible autoimmune cause of interstitial lung disease. The diagnostic pathway for SjS, however, is largely undefined in comparison to other systemic autoimmune diseases. Subjective sicca symptoms, anti-SS-A/Ro antibodies and even ANA as screening tests all have relevant limitations in sensitivity and/or specificity. Against this background, in an interdisciplinary discussion we have developed a consensus for the clarification of SjS, which is presented here for broader discussion. In addition to ANA and anti-SS-A/Ro antibodies, antibodies against alpha-fodrin should be included. Objective measures of dryness, such a Schirmer and Saxon tests are important, as is a salivary gland biopsy in the absence of typical autoantibodies.

引用

页码：321 / 324

页数：4

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