Determining the role of peroxidation of subcellular lipid membranes in ferroptosis

被引：3

作者：

von Krusenstiern, A. Nikolai ^{[1
]}

Stockwell, Brent R. ^{[1
]}

机构：

[1] Columbia Univ, New York, NY 10027 USA

来源：

NATURE CHEMICAL BIOLOGY | 2023年 / 19卷 / 06期

关键词：

D O I：

10.1038/s41589-022-01250-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferroptosis can be induced by lipid peroxidation in various subcellular membranes, including the endoplasmic reticulum (ER), mitochondria and lysosomes. By studying the subcellular distribution of ferroptosis-modulating fatty acids, we observed that the ER is a key initial site of peroxidation, followed by the plasma membrane, whereas other organelles are not as critical for ferroptosis.

引用

页码：674 / 675

页数：2

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