Major roles of the circadian clock in cancer

被引：24

作者：

Huang, Chen ^{[1
,2
]}

Zhang, Chenliang ^{[3
]}

Cao, Yubin ^{[4
]}

Li, Jian ^{[5
]}

Bi, Feng ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Canc Ctr, Dept Abdominal Oncol, Chengdu 610000, Peoples R China

[2] Sichuan Univ, West China Hosp, Lab Mol Targeted Therapy Oncol, Chengdu 610000, Peoples R China

[3] Sichuan Univ, West China Hosp, Lab Mol Targeted Therapy Oncol, Chengdu 610000, Peoples R China

[4] Sichuan Univ, West China Hosp, Dept Gastroenterol, Chengdu 610000, Peoples R China

[5] Sichuan Univ, West China Sch Med, Chengdu 610000, Peoples R China

来源：

CANCER BIOLOGY & MEDICINE | 2023年 / 20卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Circadian clock; BMAL1; cancer; tumor therapy; oncology; NUCLEAR FACTOR 4-ALPHA; CELL-PROLIFERATION; HEPATOCELLULAR-CARCINOMA; NEDD8-ACTIVATING ENZYME; COLORECTAL-CANCER; TUMOR-GROWTH; GENE PER1; TRANSCRIPTIONAL REGULATION; RHYTHM DISRUPTION; COLON-CANCER;

D O I：

10.20892/j.issn.2095-3941.2022.0474

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the processes and physiological functions of various biochemical reactions. The circadian clock is critical for cancer occurrence and progression. Its function is regulated by metabolic activities, and the expression and transcription of various genes. This review summarizes the composition of the circadian clock; the biological basis for its function; its relationship with, and mechanisms in, cancer; its various functions in different cancers; the effects of anti-tumor treatment; and potential therapeutic targets. Research in this area is expected to advance understanding of circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like protein 1 (BMAL1) in tumor diseases, and contribute to the development of new anti-tumor treatment strategies.

引用

页码：1 / 24

页数：24

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