Transforming growth factor-β signalling in tumour resistance to the anti-PD-(L)1 therapy: Updated

被引：15

作者：

Mortezaee, Keywan ^{[1
]}

Majidpoor, Jamal ^{[2
]}

机构：

[1] Kurdistan Univ Med Sci, Sch Med, Dept Anat, Sanandaj, Iran

[2] Gonabad Univ Med Sci, Infect Dis Res Ctr, Sch Med, Dept Anat, Gonabad, Iran

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2023年 / 27卷 / 03期

关键词：

immune checkpoint inhibitor; programmed death-1 receptor; programmed death-ligand 1; resistance; transforming growth factor-beta; tumour microenvironment; TGF-BETA; MYELOID CELLS; IMMUNOTHERAPY; ACTIVATION; SYNERGIZES;

D O I：

10.1111/jcmm.17666

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Low frequency of durable responses in patients treated with immune checkpoint inhibitors (ICIs) demands for taking complementary strategies in order to boost immune responses against cancer. Transforming growth factor-beta (TGF-beta) is a multi-tasking cytokine that is frequently expressed in tumours and acts as a critical promoter of tumour hallmarks. TGF-beta promotes an immunosuppressive tumour microenvironment (TME) and defines a bypass mechanism to the ICI therapy. A number of cells within the stroma of tumour are influenced from TGF-beta activity. There is also evidence of a relation between TGF-beta with programmed death-ligand 1 (PD-L1) expression within TME, and it influences the efficacy of anti-programmed death-1 receptor (PD-1) or anti-PD-L1 therapy. Combination of TGF-beta inhibitors with anti-PD(L)1 has come to the promising outcomes, and clinical trials are under way in order to use agents with bifunctional capacity and fusion proteins for bonding TGF-beta traps with anti-PD-L1 antibodies aiming at reinvigorating immune responses and promoting persistent responses against advanced stage cancers, especially tumours with immunologically cold ecosystem.

引用

页码：311 / 321

页数：11

共 106 条

[1] Molecular determinants of response to PD-L1 blockade across tumor types [J].

Banchereau, Romain ;

Leng, Ning ;

Zill, Oliver ;

Sokol, Ethan ;

Liu, Gengbo ;

Pavlick, Dean ;

Maund, Sophia ;

Liu, Li-Fen ;

Kadel, Edward, III ;

Baldwin, Nicole ;

Jhunjhunwala, Suchit ;

Nickles, Dorothee ;

Assaf, Zoe June ;

Bower, Daniel ;

Patil, Namrata ;

McCleland, Mark ;

Shames, David ;

Molinero, Luciana ;

Huseni, Mahrukh ;

Sanjabi, Shomyseh ;

Cummings, Craig ;

Mellman, Ira ;

Mariathasan, Sanjeev ;

Hegde, Priti ;

Powles, Thomas .

NATURE COMMUNICATIONS, 2021, 12 (01)

[2] SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin [J].

Bhattacharya, Apoorva ;

Mukherjee, Shravanti ;

Khan, Poulami ;

Banerjee, Shruti ;

Dutta, Apratim ;

Banerjee, Nilanjan ;

Sengupta, Debomita ;

Basak, Udit ;

Chakraborty, Sourio ;

Dutta, Abhishek ;

Chattopadhyay, Samit ;

Jana, Kuladip ;

Sarkar, Diptendra K. ;

Chatterjee, Subhrangsu ;

Das, Tanya .

SCIENCE SIGNALING, 2020, 13 (654)

[3] Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression [J].

Biswas, Swati ;

Guix, Marta ;

Rinehart, Cammie ;

Dugger, Teresa C. ;

Chytil, Anna ;

Moses, Harold L. ;

Freeman, Michael L. ;

Arteaga, Carlos L. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (05) :1305-1313

[4] Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape [J].

Bruce, Jeff P. ;

To, Ka-Fai ;

Lui, Vivian W. Y. ;

Chung, Grace T. Y. ;

Chan, Yuk-Yu ;

Tsang, Chi Man ;

Yip, Kevin Y. ;

Ma, Brigette B. Y. ;

Woo, John K. S. ;

Hui, Edwin P. ;

Mak, Michael K. F. ;

Lee, Sau-Dan ;

Chow, Chit ;

Velapasamy, Sharmila ;

Or, Yvonne Y. Y. ;

Siu, Pui Kei ;

El Ghamrasni, Samah ;

Prokopec, Stephenie ;

Wu, Man ;

Kwan, Johnny S. H. ;

Liu, Yuchen ;

Chan, Jason Y. K. ;

van Hasselt, C. Andrew ;

Young, Lawrence S. ;

Dawson, Christopher W. ;

Paterson, Ian C. ;

Yap, Lee-Fah ;

Tsao, Sai-Wah ;

Liu, Fei-Fei ;

Chan, Anthony T. C. ;

Pugh, Trevor J. ;

Lo, Kwok-Wai .

NATURE COMMUNICATIONS, 2021, 12 (01)

[5] Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition [J].

Cascio, Sandra ;

Chandler, Chelsea ;

Zhang, Linan ;

Sinno, Sarah ;

Gao, Bingsi ;

Onkar, Sayali ;

Bruno, Tullia C. ;

Vignali, Dario A. A. ;

Mahdi, Haider ;

Osmanbeyoglu, Hatice U. ;

Vlad, Anda M. ;

Coffman, Lan G. ;

Buckanovich, Ronald J. .

SCIENCE ADVANCES, 2021, 7 (46)

[6] PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production [J].

Celada, Lindsay J. ;

Kropski, Jonathan A. ;

Herazo-Maya, Jose D. ;

Luo, Weifeng ;

Creecy, Amy ;

Abad, Andrew T. ;

Chioma, Ozioma S. ;

Lee, Grace ;

Hassell, Natalie E. ;

Shaginurova, Guzel, I ;

Wang, Yufen ;

Johnson, Joyce E. ;

Kerrigan, Amy ;

Mason, Wendi R. ;

Baughman, Robert P. ;

Ayers, Gregory D. ;

Bernard, Gordon R. ;

Culver, Daniel A. ;

Montgomery, Courtney G. ;

Maher, Toby M. ;

Molyneaux, Philip L. ;

Noth, Imre ;

Mutsaers, Steven E. ;

Prele, Cecilia M. ;

Peebles, R. Stokes, Jr. ;

Newcomb, Dawn C. ;

Kaminski, Naftali ;

Blackwell, Timothy S. ;

Van Kaer, Luc ;

Drake, Wonder P. .

SCIENCE TRANSLATIONAL MEDICINE, 2018, 10 (460)

[7] An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy [J].

Chan, Sarah ;

Belmar, Nicole ;

Ho, Sun ;

Rogers, Bryan ;

Stickler, Marcia ;

Graham, Michelle ;

Lee, Eileen ;

Tran, Ninian ;

Zhang, Dong ;

Gupta, Priyanka ;

Sho, Mien ;

MacDonough, Tracy ;

Woolley, Andrew ;

Kim, Han ;

Zhang, Hong ;

Liu, Wei ;

Zheng, Pingping ;

Derso, Zoltan ;

Halliwill, Kyle ;

Ceccarelli, Michele ;

Rhodes, Susan ;

Thakur, Archana ;

Forsyth, Charles M. ;

Xiong, Mengli ;

Tan, Siu Sze ;

Iyer, Ramesh ;

Lake, Marc ;

Digiammarino, Enrico ;

Zhou, Li ;

Bigelow, Lance ;

Longenecker, Kenton ;

Judge, Russell A. ;

Liu, Cassie ;

Trumble, Max ;

Remis, Jonathan P. ;

Fox, Melvin ;

Cairns, Belinda ;

Akamatsu, Yoshiko ;

Hollenbaugh, Diane ;

Harding, Fiona ;

Alvarez, Hamsell M. .

NATURE CANCER, 2022, 3 (03) :337-+

[8] Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer [J].

Chen, Ivy X. ;

Chauhan, Vikash P. ;

Posada, Jessica ;

Ng, Mei R. ;

Wu, Michelle W. ;

Adstamongkonkul, Pichet ;

Huang, Peigen ;

Lindeman, Neal ;

Langer, Robert ;

Jain, Rakesh K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (10) :4558-4566

[9] Synthesis of molecular metallic barium superhydride: pseudocubic BaH12 [J].

Chen, Wuhao ;

Semenok, Dmitrii, V ;

Kvashnin, Alexander G. ;

Huang, Xiaoli ;

Kruglov, Ivan A. ;

Galasso, Michele ;

Song, Hao ;

Duan, Defang ;

Goncharov, Alexander F. ;

Prakapenka, Vitali B. ;

Oganov, Artem R. ;

Cui, Tian .

NATURE COMMUNICATIONS, 2021, 12 (01)

[10] Development and validation of a prognostic and predictive 32-gene signature for gastric cancer [J].

Cheong, Jae-Ho ;

Wang, Sam C. ;

Park, Sunho ;

Porembka, Matthew R. ;

Christie, Alana L. ;

Kim, Hyunki ;

Kim, Hyo Song ;

Zhu, Hong ;

Hyung, Woo Jin ;

Noh, Sung Hoon ;

Hu, Bo ;

Hong, Changjin ;

Karalis, John D. ;

Kim, In-Ho ;

Lee, Sung Hak ;

Hwang, Tae Hyun .

NATURE COMMUNICATIONS, 2022, 13 (01)

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