Recent Advances in Chemistry and Bioactivities of Secondary Metabolites from the Genus Acremonium

被引:2
作者
Qin, Yuning [1 ]
Lu, Humu [1 ]
Qi, Xin [1 ]
Lin, Miaoping [1 ]
Gao, Chenghai [1 ]
Liu, Yonghong [1 ]
Luo, Xiaowei [1 ]
机构
[1] Guangxi Univ Chinese Med, Inst Marine Drugs, Guangxi Key Lab Marine Drugs, Nanning 530200, Peoples R China
关键词
Acremonium; secondary metabolites; chemical structures; bioactivities; MARINE-DERIVED FUNGUS; SP; FUSIDIOIDES; PEPTAIBOLS;
D O I
10.3390/jof10010037
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Acremonium fungi is one of the greatest and most complex genera in Hyphomycetes, comprising 130 species of marine and terrestrial sources. The past decades have witnessed substantial chemical and biological investigations on the diverse secondary metabolites from the Acremonium species. To date, over 600 compounds with abundant chemical types as well as a wide range of bioactivities have been obtained from this genus, attracting considerable attention from chemists and pharmacologists. This review mainly summarizes the sources, chemical structures, and biological activities of 115 recently reported new compounds from the genus Acremonium from December 2016 to September 2023. They are structurally classified into terpenoids (42%), peptides (29%), polyketides (20%), and others (9%), among which marine sources are predominant (68%). Notably, these compounds were primarily screened with cytotoxic, antibacterial, and anti-inflammatory activities. This paper provides insights into the exploration and utilization of bioactive compounds in this genus, both within the scientific field and pharmaceutical industry.
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页数:19
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