Progress in direct reprogramming of dopaminergic cell replacement therapy

被引：1

作者：

Zheng, Yuan Yuan ^{[1
]}

Xu, Hui ^{[2
]}

Wang, Yue Si ^{[1
,3
,4
]}

机构：

[1] Binzhou Med Univ, Sch Pharm, Yantai 264003, Shandong, Peoples R China

[2] Binzhou Med Univ, Human Resources Dept, Yantai 264003, Shandong, Peoples R China

[3] Binzhou Med Univ, Med & Pharm Res Ctr, Yantai 264003, Shandong, Peoples R China

[4] Binzhou Med Univ, Yantai Key Lab Stem Cell & Regenerat Med, Yantai 264003, Shandong, Peoples R China

来源：

NEUROLOGICAL SCIENCES | 2024年 / 45卷 / 03期

关键词：

Parkinson's disease; Cell reprogramming; Induced dopamine neurons; Induced pluripotent stem cells; Induced neural stem cells; ADULT HUMAN FIBROBLASTS; PLURIPOTENT STEM-CELLS; PARKINSONS-DISEASE; NEURON CONVERSION; SOMATIC-CELLS; IN-VITRO; MOUSE; INDUCTION;

D O I：

10.1007/s10072-023-07175-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) is a gradual neurodegenerative disease. While drug therapy and surgical treatments have been the primary means of addressing PD, they do not offer a cure, and the risks associated with surgical treatment are high. Recent advances in cell reprogramming have given rise to new prospects for the treatment of Parkinson's disease (PD), with induced pluripotent stem cells (iPSCs), induced dopamine neurons (iDNs), and induced neural stem cells (iNSCs) being created. These cells can potentially be used in the treatment of Parkinson's disease. On the other hand, this article emphasizes the limits of iPSCs and iNSCs in the context of Parkinson's disease treatment, as well as approaches for direct reprogramming of somatic cells into iDNs. The paper will examine the benefits and drawbacks of directly converting somatic cells into iDNs.

引用

页码：873 / 881

页数：9

共 50 条

[21] A predictive computational framework for direct reprogramming between human cell types
Rackham, Owen J. L.
Firas, Jaber
Fang, Hai
Oates, Matt E.
Holmes, Melissa L.
Knaupp, Anja S.
Suzuki, Harukazu
Nefzger, Christian M.
Daub, Carsten O.
Shin, Jay W.
Petretto, Enrico
Forrest, Alistair R. R.
Hayashizaki, Yoshihide
Polo, Jose M.
Gough, Julian
NATURE GENETICS, 2016, 48 (03) : 331 - 335
[22] Direct Cell Reprogramming and Phenotypic Conversion: An Analysis of Experimental Attempts to Transform Astrocytes into Neurons in Adult Animals
Dennison, Rachel
Usuga, Esteban
Chen, Harriet
Paul, Jacob Z.
Arbelaez, Christian A.
Teng, Yang D.
CELLS, 2023, 12 (04)
[23] Concise Review: Harmonies Played by MicroRNAs in Cell Fate Reprogramming
Moradi, Sharif
Asgari, Sassan
Baharvand, Hossein
STEM CELLS, 2014, 32 (01) : 3 - 15
[24] Understanding Parkinson's Disease through the Use of Cell Reprogramming
Playne, Rebecca
Connor, Bronwen
STEM CELL REVIEWS AND REPORTS, 2017, 13 (02) : 151 - 169
[25] Past, Present, and Future of Direct Cell Reprogramming
Ahlenius, Henrik
CELLULAR REPROGRAMMING, 2022, 24 (05) : 205 - 211
[26] Gene Therapy and Cell Reprogramming for the Aging Brain: Achievements and Promise
Pardo, Joaquin
Morel, Gustavo R.
Astiz, Mariana
Schwerdt, Jose I.
Leon, Micaela L.
Rodriguez, Silvia S.
Herenu, Claudia B.
Goya, Rodolfo G.
CURRENT GENE THERAPY, 2014, 14 (01) : 24 - 34
[27] Cancer cell reprogramming: a promising therapy converting malignancy to benignity
Gong, Lanqi
Yan, Qian
Thang, Yu
Fang, Xiaona
Liu, Beilei
Guan, Xinyuan
CANCER COMMUNICATIONS, 2019, 39 (01)
[28] Targeted release of transcription factors for human cell reprogramming by ZEBRA cell-penetrating peptide
Caulier, Benjamin
Berthoin, Lionel
Coradin, Helene
Garban, Frederic
Dagher, Marie Claire
Polack, Benoit
Toussaint, Bertrand
Lenormand, Jean Luc
Laurin, David
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 529 (1-2) : 65 - 74
[29] Various Strategies of Tendon Stem/Progenitor Cell Reprogramming for Tendon Regeneration
Ahn, Sung Yong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (21)
[30] Research progress of neural stem cells as a source of dopaminergic neurons for cell therapy in Parkinson's disease
Zhang, Lingling
Yang, Hao
MOLECULAR BIOLOGY REPORTS, 2024, 51 (01)

← 1 2 3 4 5 →