Breaking the Fear Barrier: Aberrant Activity of Fear Networks as a Prognostic Biomarker in Patients with Panic Disorder Normalized by Pharmacotherapy

被引:2
作者
Yan, Haohao [1 ]
Han, Yiding [1 ]
Shan, Xiaoxiao [1 ]
Li, Huabing [2 ]
Liu, Feng [3 ]
Li, Ping [4 ]
Zhao, Jingping [1 ]
Guo, Wenbin [1 ]
机构
[1] Cent South Univ, Natl Clin Res Ctr Mental Disorders, Natl Ctr Mental Disorders, Xiangya Hosp 2,Dept Psychiat, Changsha 410011, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Dept Radiol, Changsha 410011, Peoples R China
[3] Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
[4] Qiqihar Med Univ, Dept Psychiat, Qiqihar 161006, Peoples R China
关键词
panic disorder; magnetic resonance imaging; brain; biomarker; fear; anxiety; longitudinal studies; follow-up studies; machine learning; paroxetine; COGNITIVE-BEHAVIORAL THERAPY; MAJOR DEPRESSIVE DISORDER; REGIONAL HOMOGENEITY; NEUROANATOMICAL HYPOTHESIS; DRUG-NAIVE; ASSESSMENT-TOOL; WORKING-MEMORY; ANXIETY; FMRI; 1ST-EPISODE;
D O I
10.3390/biomedicines11092420
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Panic disorder (PD) is a prevalent type of anxiety disorder. Previous studies have reported abnormal brain activity in the fear network of patients with PD. Nonetheless, it remains uncertain whether pharmacotherapy can effectively normalize these abnormalities. This longitudinal resting-state functional magnetic resonance imaging study aimed to investigate the spontaneous neural activity in patients with PD and its changes after pharmacotherapy, with a focus on determining whether it could predict treatment response. The study included 54 drug-naive patients with PD and 54 healthy controls (HCs). Spontaneous neural activity was measured using regional homogeneity (ReHo). Additionally, support vector regression (SVR) was employed to predict treatment response from ReHo. At baseline, PD patients had aberrant ReHo in the fear network compared to HCs. After 4 weeks of paroxetine treatment (20 mg/day), a significant increase in ReHo was observed in the left fusiform gyrus, which had shown reduced ReHo before treatment. The SVR analysis showed significantly positive correlations (p < 0.0001) between the predicted and actual reduction rates of the severity of anxiety and depressive symptoms. Here, we show patients with PD had abnormal spontaneous neural activities in the fear networks. Furthermore, these abnormal spontaneous neural activities can be partially normalized by pharmacotherapy and serve as candidate predictors of treatment response. Gaining insight into the trajectories of brain activity normalization following treatment holds the potential to provide vital insights for managing PD.
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页数:20
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