Mechanism of action and treatment of type I interferon in hepatocellular carcinoma

被引：5
作者：
Peng, Chunxiu [1 ]
Ye, Zhijian [1 ]
Ju, Ying [1 ]
Huang, Xiuxin [1 ]
Zhan, Chenjie [1 ]
Wei, Ke [1 ]
Zhang, Zhiyong [1 ]
机构：
[1] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & Ther, Guangxi Key Lab Biotargeting Theranost,State Key L, Nanning 530021, Guangxi, Peoples R China
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2024年 / 26卷 / 02期
关键词：
Hepatocellular carcinoma; Hepatitis B virus; Hepatitis C virus; Interferon-& beta; Interferon-& alpha; Type I interferon; FATTY LIVER-DISEASE; MESSENGER-RNA; STIMULATED GENES; DNA-DAMAGE; CELLS; BETA; SORAFENIB; CANCER; ALPHA; PROGRESSION;
D O I：
10.1007/s12094-023-03266-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatocellular carcinoma (HCC) caused by HBV, HCV infection, and other factors is one of the most common malignancies in the world. Although, percutaneous treatments such as surgery, ethanol injection, radiofrequency ablation, and transcatheter treatments such as arterial chemoembolization are useful for local tumor control, they are not sufficient to improve the prognosis of patients with HCC. External interferon agents that induce interferon-related genes or type I interferon in combination with other drugs can reduce the recurrence rate and improve survival in HCC patients after surgery. Therefore, in this review, we focus on recent advances in the mechanism of action of type I interferons, emerging therapies, and potential therapeutic strategies for the treatment of HCC using IFNs.
引用
收藏
页码：326 / 337
页数：12
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