Objective: The objective of these studies was to deter-mine the effectiveness of tylosin phosphate (TP) supple-mentation over strategic durations on the incidence and severity of liver abscesses (LA) in cattle fed in confine-ment. Materials and Methods: In Exp. 1, a total of 3,360 steers (initial BW = 377 & PLUSMN; 33 kg) were used in a random-ized complete block design with 6 treatments (48 pens; 8 replications). Treatments included no TP (NT) or TP provided the first 26% (FIRST-26), 50% (FIRST-50), or 75% (FIRST-75) or last 50% (LAST-50) of the 163-d feed-ing period or continuously for 163 d (CONT). In Exp. 2, a total of 3,625 heifers (initial BW = 267 & PLUSMN; 3 kg) were used in a randomized complete block design (48 pens; 8 replications). Treatments included no TP (NT) or TP pro-vided the first 17% (FIRST-17), 50% (FIRST-50), or 74% (FIRST-74) or last 83% (LAST-83) of the 217-d feeding period or continuously for 217 d (CONT). Results and Discussion: In Exp. 1, total percent-ages of LA were lowest for the FIRST-75 and CONT and greatest for steers in NT or LAST-50 treatments, with FIRST-26 and FIRST-50 intermediate (P < 0.01). For liv-er scores, total A+ were least for steers in the FIRST-75, which were similar to the FIRST-26, FIRST-50, and CONT (P = 0.03). Steers in NT had the greatest A+ liver abscess incidence and were similar to steers in the FIRST-26 and LAST-50 treatments. In Exp. 2, heifers in the LAST-83 and CONT treatments exhibited the low-est (P < 0.01) total LA percentage compared with NT, FIRST-17, FIRST-50, and FIRST-74 treatments. Heifers in the LAST-83 and CONT treatments had the least (P =0.04) total A+ LA compared with the greatest incidence for heifers in NT and FIRST-17 treatments. Implications and Applications: Reducing use of TP to approximately 80% of the feeding period was effective in reducing incidence of LA, although the greatest reduc-tion in LA occurred when TP was fed for the duration of the feeding period.