Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies

被引：9

作者：

Simoes Cunha, Mafalda ^{[1
]}

Amaral, Rita ^{[2
,3
,4
,5
]}

Pereira, Ana Margarida ^{[1
,2
,6
]}

Almeida, Rute ^{[3
]}

Alves-Correia, Magna ^{[1
,2
]}

Loureiro, Claudia Chaves ^{[7
]}

Lopes, Cristina ^{[8
,9
]}

Carvalho, Joana ^{[10
]}

Ribeiro, Carmelita ^{[11
]}

Vidal, Carmen ^{[12
]}

Antolin-Amerigo, Dario ^{[13
]}

Pinto, Diana ^{[14
]}

Ferreira-Magalhaes, Manuel ^{[3
,14
]}

Vasconcelos, Maria Joao ^{[15
]}

Lozoya, Carlos ^{[16
]}

Santos, Natacha ^{[17
]}

Cardia, Francisca ^{[18
]}

Taborda-Barata, Luis ^{[19
,20
,21
]}

Ferreira, Rosario ^{[22
]}

Morais Silva, Pedro ^{[23
]}

Ferreira, Tania Monteiro ^{[24
]}

Camara, Raquel ^{[25
]}

Silva, Eurico ^{[26
]}

Bordalo, Diana ^{[27
]}

Guimaraes, Cristina ^{[28
]}

Calix, Maria Jose ^{[29
]}

da Silva, Sofia ^{[30
]}

Marques, Maria Luis ^{[31
]}

Morete, Ana ^{[2
,32
]}

Nunes, Carlos ^{[33
]}

Vieira, Claudia ^{[34
]}

Pascoa, Rosalia ^{[1
,6
,35
]}

Alves, Adelaide ^{[36
]}

Marques, Jose Varanda ^{[37
]}

Reis, Bruno ^{[38
]}

Monteiro, Luis ^{[1
,39
]}

Monteiro, Rosario ^{[3
]}

Cepa, Margarida ^{[40
]}

Valentim, Bruno ^{[41
]}

Coelho, Daniela Sousa ^{[42
]}

Fernandes, Sara ^{[43
]}

Meireles, Patricia ^{[44
]}

Aguiar, Margarida Abreu ^{[45
]}

Mourao, Ana Rita ^{[46
]}

Fonseca, Joao A. ^{[2
,3
,47
]}

Jacome, Cristina ^{[3
]}

机构：

[1] Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, Porto, Portugal

[2] Inst & Hosp CUF, Allergy Unit, Porto, Portugal

[3] Univ Porto, CINTESIS RISE, MEDCIDS, Fac Med, Porto, Portugal

[4] Polytech Inst Porto, Porto Hlth Sch, Dept Cardiovasc & Resp Sci, Porto, Portugal

[5] Uppsala Univ, Dept Womens & Childrens Hlth, Paediat Res, Uppsala, Sweden

[6] Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDCI, Fac Med, Porto, Portugal

[7] Ctr Hosp & Univ Coimbra, Hosp Univ Coimbra, Pulmonol Dept, Coimbra, Portugal

[8] Univ Porto, Basic & Clin Immunol, Fac Med, Porto, Portugal

[9] Hosp Pedro Hispano, Unidade Local Saude Matosinhos, Immunoallergol, Matosinhos, Portugal

[10] Hosp Pedro Hispano, Serv Pediat, Unidade Local Saude Matosinhos, Matosinhos, Portugal

[11] Ctr Hosp & Univ Coimbra, Hosp Univ Coimbra, Serv Imunoalergol, Coimbra, Portugal

[12] Complejo Hosp Univ Santiago, Serv Alergia, Santiago De Compostella, Spain

[13] Hosp Univ Ramon & Cajal, Serv Alergia, Inst Ramon & Cajal Invest Sanit, Madrid, Spain

[14] Ctr Hosp Univ Porto, Ctr Materno Infantil Norte, Serv Pediat, Porto, Portugal

[15] Ctr Hosp Univ Sao Joao, Serv Imunoalergol, Porto, Portugal

[16] Hosp Amato Lusitano, Unidade Local Saude Castelo Branco, Allergy, Castelo Branco, Portugal

[17] Ctr Hosp Univ Algarve, Serv Imunoalergol, Portimao, Portugal

[18] Ctr Hosp Univ Algarve, Agrupamento Ctr Saude Dao Lafoes, Serv Imunoalergol, Unidade Saude Familiar Terras Azurara, Mangualde, Portugal

[19] Univ Beira Interior, CICS UBI Ctr Invest Ciencias Saude Hlth Sci Res Ct, Covilha, Portugal

[20] Univ Beira Interior, UBIAir Clin & Expt Lung Ctr, Covilha, Portugal

[21] Cova Beira Univ Hosp Ctr, Dept Allergy & Clin Immunol, Covilha, Portugal

[22] Ctr Hosp Lisboa Norte, Hosp Santa Maria, Dept Pediat, Lisbon, Portugal

[23] Grp HPA Saude, Immuno Allergol, Portimao, Portugal

[24] Agrupamento Ctr Saude Baixo Mondego, Unidade Saude Familiar Progresso Saude e, Tocha, Portugal

[25] Hosp Nossa Senhora Rosario, Ctr Hosp Barreiro Montijo, Serv Pneumol, Barreiro, Portugal

[26] Agrupamento Ctr Saude Baixo Vouga, Unidade Saude Familiar Joao Semana, Ovar, Portugal

[27] Unidade Hosp Famalicao, Serv Pediat, Ctr Hosp Medio Ave, Vila Nova De Famalicao, Portugal

[28] Agrupamento Ctr Saude Pinhal Litoral, Unidade Cuidados Saude Personalizados Norte Arnald, Monte Redondo, Portugal

[29] Ctr Hosp Tondela Viseu, Hosp Sao Teotonio, Serv Pediat, Viseu, Portugal

[30] Unidade Local Saude Alto Minho, Unidade Saude Familiar Cuidarte, Portuzelo, Portugal

[31] Hosp Senhora Oliveira, Serv Imunoalergol, Guimaraes, Guimaraes, Portugal

[32] Ctr Hosp Baixo Vouga, Hosp Infante Pedro, Serv Imunoalergol, Aveiro, Portugal

[33] Ctr Imunoalergol Algarve, Portimao, Portugal

[34] Agrupamento Ctr Saude Douro I Marao & Douro Norte, Unidade Saude Familiar Corgo, Vila Real, Portugal

[35] ACeS Porto Ocidental, Unidade Saude Familiar Homem Leme, Porto, Portugal

[36] Ctr Hosp Vila Nova Gaia Espinho, Serv Pneumol, Vila Nova DeGaia, Portugal

[37] Agrupamento Ctr Saude Dao Lafoes, Unidade Saude Familiar Viseu Cidade, Viseu, Portugal

[38] Agrupamento Ctr Saude Pinhal Litoral, Unidade Cuidados Saude Personalizados Sico, Leiria, Portugal

[39] USF Esgueira, ACES Baixo Vouga, Esgueira, Portugal

[40] ACES Pinhal Litoral, Unidade Saude Familiar Marques, Pombal, Portugal

[41] ACES Baixo Mondego, Unidade Saude Familiar Condeixa, Condeixa A Nova, Portugal

[42] ACES Tamega I Baixo Tamega, Unidade Cuidados Saude Personalizados Amarante, Amarante, Portugal

[43] ACES Cavado 1, Unidade Saude Familiar Bracara Augusta, Braga, Portugal

[44] ACES Douro II Douro Sul, Unidade Saude Familiar Almedina, Lamego, Portugal

[45] ACES Grande Porto III Maia Valongo, Unidade Saude Familiar Valongo, Valongo, Portugal

[46] ACES Grande Porto VIII Espinho Gaia, Unidade Saude Familiar Canelas, Vila Nova De Gaia, Portugal

[47] MEDIDA Med Educ Invest Desenvolvimento & Avaliacao, Porto, Portugal

来源：

BMJ OPEN | 2023年 / 13卷 / 05期

关键词：

asthma; anxiety disorders; depression & mood disorders; HOSPITAL ANXIETY; PRIMARY-CARE; ADULTS; DISORDERS; ONSET; ASSOCIATIONS; ADOLESCENTS; VALIDATION; MANAGEMENT; IMPACT;

D O I：

10.1136/bmjopen-2022-068725

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectivesAnxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Five Dimension Questionnaire (EQ-5D); the level of agreement between these questionnaires, and the factors associated with these symptoms.MethodsThis is a secondary analysis of the INSPIRERS studies. A total of 614 adolescents and adults with persistent asthma (32.6 +/- 16.9 years, 64.7% female) were recruited from 30 primary care centres and 32 allergy, pulmonology and paediatric clinics. Demographic and clinical characteristics, HADS and EQ-5D were collected. A score >= 8 on Hospital Anxiety and Depression Scale-Anxiety/Hospital Anxiety and Depression Scale-Depression or a positive answer to EQ-5D item 5 indicated the presence of these symptoms. Agreement was determined by Cohen's kappa. Two multivariable logistic regressions were built.ResultsAccording to HADS, 36% of the participants had symptoms of anxiety and 12% of depression. According to EQ-5D, 36% of the participants had anxiety/depression. The agreement between questionnaires in identifying anxiety/depression was moderate (k=0.55, 95% CI 0.48 to 0.62). Late asthma diagnosis, comorbidities and female gender were predictors of anxiety/depression, while better asthma control, health-related quality of life and perception of health were associated with lower odds for anxiety/depression.ConclusionAt least 1/3 of the patients with persistent asthma experience symptoms of anxiety/depression, showing the relevance of screening these disorders in patients with asthma. EQ-5D and HADS questionnaires showed a moderate agreement in the identification of anxiety/depression symptoms. The identified associated factors need to be further investigated in long-term studies.

引用

页数：8

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