Injectable hydroethanolic physical gels based on Codonopsis pilosula polysaccharide for sustained anticancer drug delivery

被引:13
作者
Zhao, Tingting [1 ]
Dong, Shuqing [2 ,3 ]
Shao, Shijun [2 ,3 ]
Lu, Guodi [1 ]
Hou, Jia [1 ]
Yang, Fude [1 ]
机构
[1] Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China
[2] Lanzhou Inst Chem Phys, Chinese Acad Sci, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
[3] Lanzhou Inst Chem Phys, Chinese Acad Sci, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China
基金
中国国家自然科学基金;
关键词
Codonopsis pilosula polysaccharide; Hydroethanolic physical gels; Injectable and self-recovering; STRUCTURAL-CHARACTERIZATION; RECENT PROGRESS; XYLOGLUCAN; INJECTION; HYDROGELS; GELATION;
D O I
10.1016/j.ijbiomac.2023.123178
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The development of biocompatible carriers based on hydroethanolic physical gels for effectively encapsulating and delivering hydrophobic drug molecules is of particular interest. In this paper, we reported a novel hydro-ethanolic physical gel based on Codonopsis pilosula polysaccharide (CPP) prepared from the roots of C. pilosula. The gelation behaviors of the graded CPP fractions in a water-ethanol solvent system were evaluated, and the physicochemical and mechanical properties of the CPP-based gel (CPP-G) were characterized. The results indi-cated that CPP-G had consisted of a random physically crosslinked network formed by hydrophobic association of CPP chains and exhibited good mechanical strength, higher shear-thinning sensitivity and rapid, highly efficient self-recovering characteristics, ensuring superior performance in constructing injectable and self -recovering drug-loaded gels. Hydrophobic paclitaxel (PTX) and hydrophilic doxorubicin (DOX) were used as representative drugs to investigate the encapsulation and in vitro release behaviors of CPP-G, which exhibited long-term sustained release properties. Additionally, the evaluation of drug activity in drug-loaded gels further revealed the synergistic effect of CPP-G with the selected drugs on tumor inhibition against 4T1 and MCF-7 breast cancer cell lines. This work evaluated the feasibility of using the natural polysaccharide CPP to construct hydroethanolic physical gels and the applicability of the injectable drug-loaded gels for hydrophobic drug delivery.
引用
收藏
页数:9
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