PSA testing, cancer treatment, and prostate cancer mortality reduction: What is the mechanism?

被引：13
作者：
Albertsen, Peter C. [1 ]
机构：
[1] UConn Hlth, Farmington, CT 06030 USA
来源：
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2023年 / 41卷 / 02期
关键词：
Prostate cancer; PSA screening; Prostate cancer surgery efficacy; Halsted; Fisher; Hellman theories of cancer spread; RADICAL PROSTATECTOMY; NATURAL-HISTORY; FOLLOW-UP; INTERVENTION; ANTIGEN;
D O I：
10.1016/j.urolonc.2021.08.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Any effective screening program must satisfy 2 criteria: 1) the test must identify clinically significant disease earlier than its clinical pre-sentation, and 2) a treatment must be available that will alter the natural history of the disease. The controversy surrounding PSA testing that has raged since 1991 centers on these 2 points. Screening and treatment trials published during the past 3 decades have provided critical insights into our understanding of the natural history of PSA identified cancers and the impact of treatment. This in turn raises questions concerning the mechanism of prostate cancer mortality reduction. This essay reflects on the mechanisms of disease progression and the implications for future screening and treatment efforts. (c) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码：78 / 81
页数：4
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