Effectiveness of near-UVA in SARS-CoV-2 inactivation

被引：2

作者：

Frilli, Eleonora ^{[1
]}

Amodeo, Davide ^{[2
]}

Cevenini, Gabriele ^{[3
]}

Nante, Nicola ^{[1
,2
]}

Messina, Gabriele ^{[1
,2
]}

机构：

[1] Univ Siena, Postgrad Sch Publ Hlth, Siena, Italy

[2] Univ Siena, Hyg & Prevent Med, Siena, Italy

[3] Univ Siena, Dept Med Biotechnol, Siena, Italy

来源：

EPIDEMIOLOGY AND INFECTION | 2023年 / 151卷

关键词：

COVID-19; virus infection; SARS-CoV-2; Cell Colture; near-UVA; UVC; Disinfection; Hygiene; Prevention; 405 NM LIGHT; BLUE-LIGHT; EFFICACY;

D O I：

10.1017/S0950268823000560

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This experimental study aimed to determine the activity of a near-UVA (405 nm) LED ceiling system against the SARS-CoV-2 virus. The ceiling system comprised 17 near-UVA LED lights with a radiant power of 1.1 W/each centred at 405 nm wavelength. A 96-multiwell plate, fixed to a wooden base, was inoculated with suspensions of VERO E6 cell cultures infected with SARS-CoV-2 virus and irradiated at a distance of 40 cm with a dose of 20.2 J/cm(2) for 120 min. The collected suspensions were transferred to VERO cell culture plates and incubated for 3 days. The maximum measurable log reduction obtained, starting from a concentration of 10(7.2) TCID50/mL, was 3.0 log(10) and indicated inhibition of SARS-CoV-2 replication by the near-UVA LED ceiling system. Near-UVA light at a 405-nm wavelength is emerging as a potential alternative treatment for localised infections and environmental decontamination because it is far less harmful to living organisms' cells than UV-C irradiation.

引用

页数：5