Effectiveness of near-UVA in SARS-CoV-2 inactivation

被引：5

作者：

Frilli, Eleonora ^{[1
]}

Amodeo, Davide ^{[2
]}

Cevenini, Gabriele ^{[3
]}

Nante, Nicola ^{[1
,2
]}

Messina, Gabriele ^{[1
,2
]}

机构：

[1] Univ Siena, Postgrad Sch Publ Hlth, Siena, Italy

[2] Univ Siena, Hyg & Prevent Med, Siena, Italy

[3] Univ Siena, Dept Med Biotechnol, Siena, Italy

来源：

EPIDEMIOLOGY & INFECTION | 2023年 / 151卷

关键词：

COVID-19; virus infection; SARS-CoV-2; Cell Colture; near-UVA; UVC; Disinfection; Hygiene; Prevention; 405 NM LIGHT; BLUE-LIGHT; EFFICACY;

D O I：

10.1017/S0950268823000560

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This experimental study aimed to determine the activity of a near-UVA (405 nm) LED ceiling system against the SARS-CoV-2 virus. The ceiling system comprised 17 near-UVA LED lights with a radiant power of 1.1 W/each centred at 405 nm wavelength. A 96-multiwell plate, fixed to a wooden base, was inoculated with suspensions of VERO E6 cell cultures infected with SARS-CoV-2 virus and irradiated at a distance of 40 cm with a dose of 20.2 J/cm(2) for 120 min. The collected suspensions were transferred to VERO cell culture plates and incubated for 3 days. The maximum measurable log reduction obtained, starting from a concentration of 10(7.2) TCID50/mL, was 3.0 log(10) and indicated inhibition of SARS-CoV-2 replication by the near-UVA LED ceiling system. Near-UVA light at a 405-nm wavelength is emerging as a potential alternative treatment for localised infections and environmental decontamination because it is far less harmful to living organisms' cells than UV-C irradiation.

引用

页数：5

共 27 条

[1] Efficacy of violet-blue light to inactive microbial growth [J].

Amodeo, Davide ;

Lucarelli, Valentina ;

De Palma, Isa ;

Puccio, Alessandro ;

Nante, Nicola ;

Cevenini, Gabriele ;

Messina, Gabriele .

SCIENTIFIC REPORTS, 2022, 12 (01)

[2]

[Anonymous], EUROPEAN OPHTHAL REV

[3]

[Anonymous], PHOTOBIOLOGICAL SAFE

[4]

[Anonymous], EYE COMPLICATIONS EX

[5] Violet 405-nm light: a novel therapeutic agent against common pathogenic bacteria [J].

Barneck, Mitchell D. ;

Rhodes, Nathaniel L. R. ;

de la Presa, Martin ;

Allen, James P. ;

Poursaid, Ahrash E. ;

Nourian, Maziar M. ;

Firpo, Matthew A. ;

Langell, John T. .

JOURNAL OF SURGICAL RESEARCH, 2016, 206 (02) :316-324

[6] Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses [J].

Buonanno, Manuela ;

Welch, David ;

Shuryak, Igor ;

Brenner, David J. .

SCIENTIFIC REPORTS, 2020, 10 (01)

[7]

COVID-19 Map-Johns Hopkins Coronavirus Resource Center, US

[8] The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 [J].

Gorbalenya, Alexander E. ;

Baker, Susan C. ;

Baric, Ralph S. ;

de Groot, Raoul J. ;

Drosten, Christian ;

Gulyaeva, Anastasia A. ;

Haagmans, Bart L. ;

Lauber, Chris ;

Leontovich, Andrey M. ;

Neuman, Benjamin W. ;

Penzar, Dmitry ;

Perlman, Stanley ;

Poon, Leo L. M. ;

Samborskiy, Dmitry V. ;

Sidorov, Igor A. ;

Sola, Isabel ;

Ziebuhr, John .

NATURE MICROBIOLOGY, 2020, 5 (04) :536-544

[9] Light as a Broad-Spectrum Antimicrobial [J].

Gwynne, Peter J. ;

Gallagher, Maurice P. .

FRONTIERS IN MICROBIOLOGY, 2018, 9

[10] Control Measures for SARS-CoV-2: A Review on Light-Based Inactivation of Single-Stranded RNA Viruses [J].

Hadi, Joshua ;

Dunowska, Magdalena ;

Wu, Shuyan ;

Brightwell, Gale .

PATHOGENS, 2020, 9 (09) :1-30

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