Micronutrients and cognitive functions among urban school-going children and adolescents: A cross-sectional multicentric study from India

被引：7

作者：

Singh, Shweta ^{[1
]}

Awasthi, Shally ^{[2
]}

Kumar, Divas ^{[2
]}

Sarraf, Seema Rani ^{[1
]}

Pandey, Anuj Kumar ^{[2
]}

Agarwal, Girdhar G. ^{[3
]}

Awasthi, Avivar ^{[4
]}

Anish, T. S. ^{[5
]}

Mathew, Joseph L. ^{[6
]}

Kar, Sonali ^{[7
]}

Nair, Suma ^{[8
]}

Rao, Chythra R. ^{[8
]}

Pande, Harsh ^{[2
]}

Mahanta, B. N. ^{[9
]}

Bharti, Bhavneet ^{[6
]}

Singh, C. M. ^{[10
]}

Singh, Kuldeep ^{[11
]}

Bhat, Mushtaq A. ^{[12
]}

Somashekar, A. R. ^{[13
]}

Awasthi, Rajiv ^{[14
]}

Mahdi, Abbas Ali ^{[15
]}

机构：

[1] King Georges Med Univ, Dept Psychiat, Lucknow, Uttar Pradesh, India

[2] King Georges Med Univ, Dept Pediat, Lucknow, Uttar Pradesh, India

[3] Univ Lucknow, Dept Stat, Lucknow, Uttar Pradesh, India

[4] Med Coll, Dept Endocrinol, Kolkata, India

[5] Govt Med Coll, Dept Community Med, Thiruvananthapuram, Kerela, India

[6] Post Grad Inst Med Sci, Dept Pediat Med, Chandigarh, India

[7] Kalinga Inst Med Sci, Dept Community Med, Bhubaneswar, Orissa, India

[8] Kasturba Med Coll & Hosp, Dept Community Med, Manipal, Karnataka, India

[9] Assam Med Coll, Dept Med, Dibrugarh, Assam, India

[10] All India Inst Med Sci, Dept Community & Family Med, Patna, Bihar, India

[11] All India Inst Med Sci, Dept Pediat, Jodhpur, Rajasthan, India

[12] Sherikashmir Inst Med Sci, Dept Pediat, Srinagar, Jammu & Kashmir, India

[13] MS Ramaiah Inst Med Sci, Dept Pediat, Bangalore, Karnataka, India

[14] Prarthana Diabetic Care Ctr, Lucknow, Uttar Pradesh, India

[15] King Georges Med Univ, Dept Biochem, Lucknow, Uttar Pradesh, India

来源：

PLOS ONE | 2023年 / 18卷 / 02期

关键词：

NUTRITIONAL-STATUS; FOLATE STATUS; SCHOOLCHILDREN; PERFORMANCE; DEFICIENCY; VITAMIN-B-12; INTELLIGENCE; PREVALENCE; EDUCATION; IRON;

D O I：

10.1371/journal.pone.0281247

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BackgroundMicronutrient deficiency (MD) is associated with deficits in cognitive functioning of children. However, no comprehensive multicentric study has been conducted in India to explore the role of multiple MD in cognition of children and adolescents. The present study aimed to explore association of MD with level of general intelligence and specific cognitive functions, in urban school-going children and adolescents across ten cities of India. MethodCross-sectional multicentric study, enrolled participants aged 6-16 years. Blood samples were collected for biochemical analysis of calcium, iron, zinc, selenium, folate, vitamin A, D and B12. Colored Progressive Matrices / Standard Progressive Matrices (CPM/SPM), Coding, Digit Span and Arithmetic tests were used for the assessment of cognitive functions of participants. Height and weight measures were collected along with socio-economic status. ResultsFrom April-2019 to February-2020, 2428 participants were recruited from 60 schools. No MD was found in 7.0% (134/1918), any one MD in 23.8% (457/1918) and >= 2 MD in 69.2% (1327/1918) participants. In presence of >= 2 MD, adjusted odds ratio (OR) for borderline or dull normal in CPM/SPM was 1.63, (95% CI: 1.05-2.52), coding was 1.66 (95% CI: 1.02-2.71), digit span was 1.55 (95% CI: 1.06-2.25) and arithmetic was 1.72 (95% CI: 1.17-2.53), controlling for gender, socioeconomic status and anthropometric indicators. ConclusionSince >= 2 MD were found in more than 2/3rd of participants and was associated with impairment in cognitive function, attempts must be made to ameliorate them on priority in school going children in India.

引用

页数：14

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