Comparison of two high dose rate intracavitary brachytherapy regimens in treatment of cervical cancer: a preliminary report

被引：4

作者：

Krishna, Abhishek ^{[1
]}

Hasib, A. G. ^{[2
]}

Fernandes, Donald ^{[2
]}

Athiyamaan, M. S. ^{[1
]}

Rao, Sandesh ^{[2
]}

Shankar, Sharaschandra ^{[2
]}

Ali, Mohsina ^{[3
]}

Priyadarshini, Hepsiba ^{[2
]}

Sophia, Maria ^{[2
]}

Shridhar, C. H. ^{[2
]}

George, Seby ^{[2
]}

Babu, Amrutha ^{[2
]}

Banerjee, Sourjya ^{[1
,2
]}

Sunny, Johan ^{[1
]}

Srinivas, Challapalli ^{[1
]}

Lobo, Dilson ^{[1
]}

机构：

[1] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Radiat Oncol, Mangalore, India

[2] Father Muller Med Coll, Dept Radiat Oncol, Mangalore, India

[3] Sultan Qaboos Univ, Muscat, Oman

来源：

DISCOVER ONCOLOGY | 2023年 / 14卷 / 01期

关键词：

Carcinoma cervix; Brachytherapy; Intracavitary radiotherapy; TREATMENT TIME; CARCINOMA; CISPLATIN;

D O I：

10.1007/s12672-023-00646-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundTo assess and compare the local control and toxicities between HDR Intracavitary Brachytherapy with 7.5 Gy and 9 Gy per fraction after EBRT in treatment of carcinoma cervix.MethodologyA total of 180 patients were randomly assigned to 2 arms. Arm A received HDR intracavitary brachytherapy with a dose of 7.5 Gy per fraction, 1 fraction per week for 3 fractions and Arm B received 9 Gy per fraction, 1 fraction per week for 2 fractions. Patients were evaluated on follow up for assessment of local control and toxicities.ResultsThe median follow up was 12 months (6-18 months). In arm A 89% of the patient had complete response and 11% had recurrence or metastasis. In arm B 93% of the patient had complete response and 7% had recurrence or metastasis. Grade 2/3 diarrhoea was seen in 4.4% of patients in Arm A and in 7.7% in Arm B. Grade 2/3 proctitis was seen in 3.3% of patients in 7.5 Gy arm and in 6.6% in 9 Gy arm. One patient in each arm had grade 1 haematuria. The overall duration of treatment was significant lower in Arm B compared to Arm A (59 days vs 68 days, p = 0.01).ConclusionThe result of this clinical study shows that Intracavitary brachytherapy with a dose of 9 Gy per fraction is non inferior to other schedules in term of local control and does not result in increased toxicity.

引用

页数：9

共 22 条

[21] Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].

Sung, Hyuna ;

Ferlay, Jacques ;

Siegel, Rebecca L. ;

Laversanne, Mathieu ;

Soerjomataram, Isabelle ;

Jemal, Ahmedin ;

Bray, Freddie .

CA-A CANCER JOURNAL FOR CLINICIANS, 2021, 71 (03) :209-249

[22]

Viswanathan A.N., 2013, Principles and Practice of Radiatiation Oncology, V6th, P1355

← 1 2 3 →