Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

被引：113
作者：
Wei, Chuang [1 ]
Jiang, Zeyu [2 ]
Li, Congcong [1 ]
Li, Peifeng [1 ]
Fu, Qinrui [1 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Inst Translat Med, Coll Med, Qingdao 266021, Peoples R China
[2] Qingdao Univ, Affiliated Hosp, Coll Med, Dept Cardiovasc Med, Qingdao 266021, Peoples R China
来源：
ADVANCED FUNCTIONAL MATERIALS | 2023年 / 33卷 / 26期
基金：
中国国家自然科学基金;
关键词：
cardiovascular diseases; diagnosis; endogenous biomarkers; nanomaterials; therapy; SMOOTH-MUSCLE-CELLS; VULNERABLE ATHEROSCLEROTIC PLAQUE; ACUTE MYOCARDIAL-INFARCTION; DRUG-DELIVERY SYSTEM; ANTI-PEG ANTIBODIES; OXYGEN SPECIES ROS; PHOTODYNAMIC THERAPY; HEART-FAILURE; IN-VIVO; ADHESION MOLECULE-1;
D O I：
10.1002/adfm.202214655
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels the development of advanced technologies for CVD diagnosis and treatment. Biomarker-responsive nanomaterials are appealing therapeutic platforms that provide new horizons for CVD theranostics. In this review, recent advances in nanomaterials with endogenous biomarkers as stimuli or targets for CVD theranostics is presented. First, the categories of biomarkers involved are comprehensively itemized based on pathological mechanisms including pH, reactive oxygen species, lipids, enzymes, macrophage receptors, subendothelium components, platelet receptors, inflammation, and osteopontin. The role of these biomarkers in bridge-building between nanomaterials and CVD is then presented. Next, the biomedical applications of nanomaterials responsive to endogenous biomarkers as stimuli or targets for the diagnosis and treatment of CVD are elaborated. Finally, the challenges and future research directions of biomarker-responsive nanomaterials in CVD are also discussed. This review will provide scientific guidance to facilitate clinical applications of biomarker-responsive nanomaterials.
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收藏
页数：42
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